Differentiating Liver Hemangioma from Metastatic Tumor Using T2-enhanced Spin-echo Imaging with a Time-reversed Gradient-echo Sequence in the Hepatobiliary Phase of Gadoxetic Acid-enhanced MR Imaging.

IF 2.5 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Magnetic Resonance in Medical Sciences Pub Date : 2022-07-01 Epub Date: 2021-04-20 DOI:10.2463/mrms.mp.2020-0151
Yukihisa Takayama, Akihiro Nishie, Daisuke Okamoto, Nobuhiro Fujita, Yoshiki Asayama, Yasuhiro Ushijima, Tomoharu Yoshizumi, Masami Yoneyama, Kousei Ishigami
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引用次数: 4

Abstract

Purpose: To evaluate the utility of T2-enhanced spin-echo imaging using the time-reversed gradient echo sequence (T2FFE imaging) in the hepatobiliary phase (HBP) of gadoxetic acid-enhanced MRI (Gd-EOB-MRI) for differentiating hemangiomas from metastatic tumors.

Methods: A total of 61 patients with 133 liver lesions, including 37 hemangiomas and 96 metastatic tumors, were scanned by Gd-EOB-MRI. Four data sets were independently analyzed by two readers: (1) 3D fat-suppressed T2-weighted imaging (FS-T2WI) alone; (2) the combination of 3D FS-T2WI and T2FFE imaging in the HBP of Gd-EOB-MRI; (3) the combination of 3D FS-T2WI, diffusion-weighted imaging (DWI) with the b-value of 1000 s/mm2 and the apparent diffusion coefficient (ADC); and (4) a dynamic study of Gd-EOB-MRI. After classifying the lesion sizes as ≤ 10 mm or > 10 mm, we conducted a receiver-operating characteristic analysis to compare diagnostic accuracies among the four data sets for differentiating hemangiomas from metastatic tumors.

Results: The areas under the curves (AUCs) of the four data sets of two readers were: (1) ≤ 10 mm (0.85 and 0.91) and > 10 mm (0.88 and 0.97), (2) ≤ 10 mm (0.94 and 0.94) and > 10 mm (0.96 and 0.95), (3) ≤ 10 mm (0.90 and 0.87) and > 10 mm (0.89 and 0.95), and (4) ≤ 10 mm (0.62 and 0.67) and > 10 mm (0.76 and 0.71), respectively. Data sets (2) and (3) showed no significant differences in AUCs, but both showed significantly higher AUCs compared to that of (4) regardless of the lesion size (P < 0.05).

Conclusion: The combination of 3D FS-T2WI and T2FFE imaging in the HBP of Gd-EOB-MRI achieved an accuracy equivalent to that of the combination of 3D FS-T2WI, DWI, and ADC and might be helpful in differentiating hemangiomas from metastatic tumors.

Abstract Image

Abstract Image

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利用t2增强自旋回波成像和加多西酸增强的肝胆期梯度回波序列鉴别肝血管瘤和转移性肿瘤。
目的:评价加多乙酸增强MRI (Gd-EOB-MRI)在肝胆期(HBP)使用时间反转梯度回波序列(T2FFE成像)的t2增强自旋回波成像在鉴别血管瘤和转移性肿瘤中的应用价值。方法:采用Gd-EOB-MRI扫描61例肝脏病变133例,其中血管瘤37例,转移瘤96例。四个数据集由两位读者独立分析:(1)单独的3D脂肪抑制t2加权成像(FS-T2WI);(2) 3D FS-T2WI与T2FFE联合成像在Gd-EOB-MRI中对HBP的诊断;(3)三维FS-T2WI、b值为1000 s/mm2的弥散加权成像(DWI)与表观弥散系数(ADC)相结合;(4) Gd-EOB-MRI动态研究。在将病变大小分为≤10mm或> 10mm后,我们进行了受体操作特征分析,以比较四个数据集在区分血管瘤和转移瘤方面的诊断准确性。结果:2个阅读器4个数据集的曲线下面积(auc)分别为:(1)≤10 mm(0.85和0.91)和> 10 mm(0.88和0.97),(2)≤10 mm(0.94和0.94)和> 10 mm(0.96和0.95),(3)≤10 mm(0.90和0.87)和> 10 mm(0.89和0.95),(4)≤10 mm(0.62和0.67)和> 10 mm(0.76和0.71)。数据集(2)和(3)的auc差异无统计学意义,但与(4)相比,无论病变大小,数据集(2)和(3)的auc均显著升高(P < 0.05)。结论:3D FS-T2WI和T2FFE联合在Gd-EOB-MRI的HBP中具有与3D FS-T2WI、DWI和ADC联合成像相当的准确性,可能有助于血管瘤与转移性肿瘤的鉴别。
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来源期刊
Magnetic Resonance in Medical Sciences
Magnetic Resonance in Medical Sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
5.80
自引率
20.00%
发文量
71
审稿时长
>12 weeks
期刊介绍: Magnetic Resonance in Medical Sciences (MRMS or Magn Reson Med Sci) is an international journal pursuing the publication of original articles contributing to the progress of magnetic resonance in the field of biomedical sciences including technical developments and clinical applications. MRMS is an official journal of the Japanese Society for Magnetic Resonance in Medicine (JSMRM).
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