Adding wisdom to 'smart' bioelectronic systems: a design framework for physiologic control including practical examples.

Bioelectronics in medicine Pub Date : 2019-03-01 Epub Date: 2019-05-30 DOI:10.2217/bem-2019-0008
Aysegul Gunduz, Enrico Opri, Ro'ee Gilron, Vaclav Kremen, Gregory Worrell, Phil Starr, Kent Leyde, Timothy Denison
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Abstract

This perspective provides an overview of how risk can be effectively considered in physiological control loops that strive for semi-to-fully automated operation. The perspective first introduces the motivation, user needs and framework for the design of a physiological closed-loop controller. Then, we discuss specific risk areas and use examples from historical medical devices to illustrate the key concepts. Finally, we provide a design overview of an adaptive bidirectional brain-machine interface, currently undergoing human clinical studies, to synthesize the design principles in an exemplar application.

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为 "智能 "生物电子系统增添智慧:包括实例在内的生理控制设计框架。
本视角概述了如何在力求实现半自动到全自动操作的生理控制回路中有效考虑风险。本视角首先介绍了设计生理闭环控制器的动机、用户需求和框架。然后,我们讨论了特定的风险领域,并使用历史医疗设备的实例来说明关键概念。最后,我们概述了一个自适应双向脑机接口的设计,该接口目前正在进行人体临床研究,并在示例应用中综合了设计原则。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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