Role of hydrogen in traumatic brain injury: a narrative review.

IF 3 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Gas Research Pub Date : 2021-07-01 DOI:10.4103/2045-9912.314331

Hong-Wei Hu, Zhi-Guo Chen, Jian-Gang Liu, Gang Chen

引用次数: 8

Abstract

Traumatic brain injury (TBI) is a serious global public health problem. Survivors of TBI often suffer from long-term disability, which puts a heavy burden on society and families. Unfortunately, up to now, there is no efficacious treatment for TBI patients in clinical practice. As a reducing gas, hydrogen has been shown to be neuroprotective in multiple cerebral disease models; however, its efficacy in TBI remains controversial. In this review, we will focus on the results of hydrogen in experimental TBI, elaborate the potential mechanisms, and put forward for future researches based on our current understanding and views.

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氢在创伤性脑损伤中的作用:综述。

外伤性脑损伤(TBI)是一个严重的全球性公共卫生问题。创伤性脑损伤的幸存者往往遭受长期残疾，这给社会和家庭带来了沉重的负担。遗憾的是，到目前为止，临床上对TBI患者还没有有效的治疗方法。作为还原性气体，氢在多种脑疾病模型中显示出神经保护作用;然而，其治疗创伤性脑损伤的疗效仍有争议。在本文中，我们将重点介绍氢在实验性脑损伤中的研究结果，阐述其可能的机制，并根据我们目前的认识和观点对未来的研究提出建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Gas Research MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

5.10

自引率

13.80%

发文量

期刊介绍： Medical Gas Research is an open access journal which publishes basic, translational, and clinical research focusing on the neurobiology as well as multidisciplinary aspects of medical gas research and their applications to related disorders. The journal covers all areas of medical gas research, but also has several special sections. Authors can submit directly to these sections, whose peer-review process is overseen by our distinguished Section Editors: Inert gases - Edited by Xuejun Sun and Mark Coburn, Gasotransmitters - Edited by Atsunori Nakao and John Calvert, Oxygen and diving medicine - Edited by Daniel Rossignol and Ke Jian Liu, Anesthetic gases - Edited by Richard Applegate and Zhongcong Xie, Medical gas in other fields of biology - Edited by John Zhang. Medical gas is a large family including oxygen, hydrogen, carbon monoxide, carbon dioxide, nitrogen, xenon, hydrogen sulfide, nitrous oxide, carbon disulfide, argon, helium and other noble gases. These medical gases are used in multiple fields of clinical practice and basic science research including anesthesiology, hyperbaric oxygen medicine, diving medicine, internal medicine, emergency medicine, surgery, and many basic sciences disciplines such as physiology, pharmacology, biochemistry, microbiology and neurosciences. Due to the unique nature of medical gas practice, Medical Gas Research will serve as an information platform for educational and technological advances in the field of medical gas.