Mitochondrial DNA Diversity and Evolutionary History of Native Human Populations of Argentinean Northwest Patagonia.

4区 生物学 Q2 Medicine
Maria Bárbara Postillone, Virginia A Cobos, Celmira Urrutia, Cristina Dejean, Paula N Gonzalez, S Ivan Perez, Valeria Bernal
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引用次数: 3

Abstract

The genetic composition of Amerindian descendants from Patagonia has long been a focus of interest, although the information available is still scarce for many geographic areas. Here, we report the first analysis of the variation in the mitochondrial DNA (mtDNA) control region for an area of northwestern Patagonia, the North of Neuquén, with the aim of studying the processes and historical events that modeled the evolutionary history of these human groups. We analyzed 113 individuals from two localities of northern Neuquén, along with 6 from southern Neuquén and 223 previously published mtDNA sequences from neighboring areas in Argentina and Chile. We estimated the haplotypic variation and spatial structure of molecular variability. Amerindian subhaplogroups predominate in the two samples from northern Neuquén (n = 70), with D1g and C1b13 the most represented, although in different proportions. These samples exhibit Amerindian mtDNA haplotypes similar to the variants from neighboring areas. Most of haplotype variability was within group; variation among groups was relatively low and scarcely associated with geographical space. The most frequent subhaplogroups in northern Neuquén are characteristic of native populations from Patagonia and Chilean Araucanía, and probably originated in the region during the Late Pleistocene or Early Holocene. However, the spatial variation of mtDNA haplotypes departs from a latitudinal pattern and suggests differential levels of gene flow among areas during the Late Holocene, with moderate levels across the North of Neuquén as well as between this area and neighboring populations from Chile, the South of Neuquén, and Río Negro.

阿根廷西北巴塔哥尼亚土著人群线粒体DNA多样性和进化历史。
巴塔哥尼亚美洲印第安人后裔的基因组成长期以来一直是人们关注的焦点,尽管在许多地理区域,可用的信息仍然很少。在这里,我们首次报道了对巴塔哥尼亚西北部地区的线粒体DNA (mtDNA)控制区变异的分析,目的是研究这些人类群体进化历史的过程和历史事件。我们分析了来自北部两个地区的113个个体,以及来自南部的6个个体,以及来自阿根廷和智利邻近地区的223个先前发表的mtDNA序列。我们估计了分子变异的单倍型变异和空间结构。美国印第安人亚单倍群在neuqusamn北部的两个样本中占主导地位(n = 70),其中D1g和C1b13最具代表性,尽管比例不同。这些样本显示美洲印第安人的mtDNA单倍型与邻近地区的变体相似。单倍型变异主要发生在群体内;群体间变异相对较低,与地理空间关系不大。neuqusamn北部最常见的亚单倍群是巴塔哥尼亚和智利Araucanía土著种群的特征,可能起源于晚更新世或全新世早期。然而,mtDNA单倍型的空间变异偏离了纬度模式,表明在全新世晚期,不同地区之间的基因流动水平存在差异,在neuqusamen北部以及该地区与邻近的智利、neuqusamen南部和Río Negro人群之间的基因流动水平中等。
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来源期刊
Human Biology
Human Biology 生物-生物学
CiteScore
1.90
自引率
0.00%
发文量
88
审稿时长
>12 weeks
期刊介绍: Human Biology publishes original scientific articles, brief communications, letters to the editor, and review articles on the general topic of biological anthropology. Our main focus is understanding human biological variation and human evolution through a broad range of approaches. We encourage investigators to submit any study on human biological diversity presented from an evolutionary or adaptive perspective. Priority will be given to interdisciplinary studies that seek to better explain the interaction between cultural processes and biological processes in our evolution. Methodological papers are also encouraged. Any computational approach intended to summarize cultural variation is encouraged. Studies that are essentially descriptive or concern only a limited geographic area are acceptable only when they have a wider relevance to understanding human biological variation. Manuscripts may cover any of the following disciplines, once the anthropological focus is apparent: human population genetics, evolutionary and genetic demography, quantitative genetics, evolutionary biology, ancient DNA studies, biological diversity interpreted in terms of adaptation (biometry, physical anthropology), and interdisciplinary research linking biological and cultural diversity (inferred from linguistic variability, ethnological diversity, archaeological evidence, etc.).
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