Innate immunity: Trained immunity and innate allorecognition against the allograft.

IF 4.3 4区 医学 Q2 IMMUNOLOGY
International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-05-03 DOI:10.1080/08830185.2021.1921175
Mohammad Mirzakhani, Mehdi Shahbazi, Sara Shamdani, Sina Naserian, Mousa Mohammadnia-Afrouzi
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引用次数: 7

Abstract

The immune system response of transplant recipients is the main cause of allograft rejection; therefore, its suppression seems crucial. Nevertheless, immunosuppressive agents are largely ineffective against innate immune response. Innate immunity is immediately activated after transplantation and contribute to allograft inflammation and rejection. In this regard, understanding the mechanism of activation and targeting the components of innate immunity could improve allograft survival time. In this review, we discuss two scenarios in the innate immunity, i.e., danger and allogeneic signals in the context of both allogeneic and syngeneic graft. Moreover, the mechanisms of innate allorecognition (i.e., signal regulatory protein α-CD47 and paired immunoglobulin-like receptors-MHC I axis) are described, which can improve our clinical decisions to use a better therapeutic strategy.

先天免疫:针对同种异体移植物的训练免疫和先天异体识别。
移植受者的免疫系统反应是引起同种异体移植排斥反应的主要原因;因此,抑制它似乎至关重要。然而,免疫抑制剂在很大程度上对先天免疫反应无效。先天免疫在移植后立即被激活,导致同种异体移植物的炎症和排斥反应。在这方面,了解激活机制和靶向先天免疫成分可以提高同种异体移植物的存活时间。本文综述了同种异体和同基因移植物在先天免疫中的两种情况,即危险信号和同种异体信号。此外,本文还描述了先天异体识别的机制(即信号调节蛋白α-CD47和配对的免疫球蛋白样受体- mhc I轴),这可以改善我们的临床决策,以使用更好的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
11.00
自引率
4.00%
发文量
24
期刊介绍: This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).
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