Sex ratio of infants born through in vitro fertilization and embryo transfer: Results of a single-institution study and literature review.

IF 1.9

JBRA assisted reproduction Pub Date : 2021-07-21 DOI:10.5935/1518-0557.20200096

Chinatsu Nagata, Keiko Mekaru, Keiya Gibo, Rie Nakamura, Sugiko Oishi, Maho Miyagi, Kozue Akamine, Yoichi Aoki

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引用次数: 1

Abstract

Objective: The possible effects of Assisted Reproductive Technology (ART) on sex ratio at birth are extremely significant. This study aimed to determine whether ART affects the sex ratio of infants born through in vitro fertilization and embryo transfer (IVF-ET).

Materials and methods: We ran this retrospective study on 290 singleton infants born following IVF-ET from February 2014 to August 2018 at a single institution. We compared the sex ratios of these infants with respect to insemination versus intracytoplasmic sperm injection (ICSI), early-cleavage embryo versus blastocyst transfer, fresh versus frozen-thawed embryo transfer and normal sperm versus asthenospermia.

Results: There were no significant differences in the sex ratio with respect to the fertilization method, transfer time, fresh embryo or frozen-thawed embryo transfer. In addition, the multiple logistic regression analysis revealed that these factors did not significantly affect the sex ratio.

Conclusions: Our study indicated that the differences in the fertilization method transfer time and sperm motility rate did not affect the sex ratio of IVF live births. However, with increasing numbers of ICSI and blastocyst transfer cycles, factors possibly affecting the sex ratio need to be further investigated.

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通过体外受精和胚胎移植出生的婴儿的性别比例:一项单机构研究和文献综述的结果。

目的:辅助生殖技术(ART)对出生性别比的影响是非常显著的。本研究旨在确定ART是否会影响通过体外受精和胚胎移植(IVF-ET)出生的婴儿的性别比例。材料和方法:我们对2014年2月至2018年8月在一家机构IVF-ET后出生的290名单胎婴儿进行了回顾性研究。我们比较了这些婴儿的性别比例，包括人工授精与卵浆内单精子注射(ICSI)、早裂胚胎与囊胚移植、新鲜胚胎与冷冻解冻胚胎移植、正常精子与弱精子症。结果:受精方式、移植时间、新鲜胚胎与冻融胚胎移植对性别比无显著影响。此外，多元逻辑回归分析显示，这些因素对性别比没有显著影响。结论:我们的研究表明，受精方式、转移时间和精子运动率的差异对IVF活产婴儿的性别比没有影响。然而，随着ICSI和囊胚移植周期的增加，可能影响性别比例的因素需要进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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JBRA assisted reproduction

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