Pregnancy Loss After Amniocentesis and Chorionic Villus Sampling: Cohort Study.

IF 1.6 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Zdravstveno Varstvo Pub Date : 2020-12-31 eCollection Date: 2020-12-01 DOI:10.2478/sjph-2021-0005

Ivana Paljk Likar, Ksenija Slavec Jere, Teja Možina, Ivan Verdenik, Nataša Tul

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引用次数: 0

Abstract

Introduction: Introduction: To estimate the procedure-related risks of pregnancy loss following chorionic villus sampling (CVS) and amniocentesis (AC) compared to pregnancies without procedure.

Methods: This cohort study enrolled all women who underwent CVS or AC at the Department of Perinatology, University Medical Centre, Ljubljana, Slovenia (from January 2013 to June 2015). For each group we obtained a maternal age and gestational age (11-14 weeks for CVS and >15 weeks for AC) for a matched control group without invasive procedures from the national database. The data was obtained from hospital records and telephone surveys concerning pregnancy outcomes. Pregnancy loss rates in intervention vs. control groups were compared by generating relative risk (RR) with a 95% confidence interval.

Results: During the study period, 828 women underwent CVS and 2,164 women underwent AC. Complete outcome data was available in 2,798 cases (93.5%, 770 CVS, 2,028 AC). Pregnancy loss occurred in 8/770 (1.04%, 95% CI 0.4-2.0%) after CVS vs. 15/1130 (1.33%, 95% CI 0.8-2.2%) in matched control (RR 0.8, 95% CI 0.33-1.8, p=0.6). It occurred in 16/2028 (0.79%, 95% CI 0.5-1.3%) after AC vs. 14/395 (3.29%, 95% CI 2.1-5.8%) in matched control (RR 0.2, 95% CI 0.11-0.45, p<0.0001).

Conclusion: The pregnancy loss rates after CVS and AC were comparable to losses in pregnancies without these procedures. With the increasing use of non-invasive prenatal testing, information that the invasive procedures are safe when indicated is essential.

查看原文本刊更多论文

羊膜腔穿刺术和绒毛取样术后的妊娠损失：队列研究。

导言简介：目的：估计绒毛取样（CVS）和羊膜穿刺术（AC）后与手术相关的妊娠损失风险：目的：估算绒毛取样（CVS）和羊膜穿刺术（AC）与未经手术的妊娠相比，发生妊娠损失的手术相关风险：这项队列研究招募了所有在斯洛文尼亚卢布尔雅那大学医学中心围产医学部接受绒毛膜促性腺激素检查或羊水穿刺术的女性（2013 年 1 月至 2015 年 6 月）。我们从国家数据库中获取了每组产妇的年龄和孕周（CVS 为 11-14 周，AC>15 周），以及未接受侵入性手术的匹配对照组。数据来自医院记录和有关妊娠结果的电话调查。通过计算相对风险（RR）和 95% 的置信区间，比较了干预组和对照组的妊娠损失率：研究期间，828 名妇女接受了 CVS 检查，2164 名妇女接受了 AC 检查。有 2798 例（93.5%，770 例 CVS，2028 例 AC）获得了完整的结果数据。接受 CVS 后，8/770（1.04%，95% CI 0.4-2.0%）例患者发生妊娠丢失，而匹配对照组为 15/1130（1.33%，95% CI 0.8-2.2%）例（RR 0.8，95% CI 0.33-1.8，P=0.6）。AC 后 16/2028 例（0.79%，95% CI 0.5-1.3%）与匹配对照的 14/395 例（3.29%，95% CI 2.1-5.8%）（RR 0.2，95% CI 0.11-0.45，P=0.6）相比，发生了妊娠损失：CVS和AC术后的妊娠损失率与未进行这些手术的妊娠损失率相当。随着无创产前检测的使用越来越多，有必要提供信息说明有创产前检测是安全的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zdravstveno Varstvo PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

3.00

自引率

20.00%

发文量

审稿时长

23 weeks