Highly integrated CMOS microsystems to interface with neurons at subcellular resolution.

Abstract

CMOS high-density transducer arrays enable fundamentally new neuroscientific insights through, e.g., facilitating investigation of axonal signaling characteristics, with the "axonal" side of neuronal activity being largely inaccessible to established methods. They also enable high-throughput monitoring of potentially all action potentials in a larger neuronal network (> 1000 neurons) over extended time to see developmental effects or effects of disturbances. Applications include research in neural diseases and pharmacology.