Physical Function in Kidney Transplantation: Current Knowledge and Future Directions.

IF 1.6 Q2 SURGERY

Current Transplantation Reports Pub Date : 2020-06-01 Epub Date: 2020-05-02 DOI:10.1007/s40472-020-00271-5

Dia Yang, Lucy Robinson, Christian Selinski, Thalia Bajakian, Christina Mejia, Meera Nair Harhay

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引用次数: 6

Abstract

Purpose of review: Low physical function (PF) is common among individuals with end-stage kidney disease. In this review, we explore data on the impacts of PF on access to kidney transplantation (KT) and KT outcomes. We also discuss the latest interventions to improve PF in pre- and post-KT settings.

Recent findings: Many US KT programs measure PF or related constructs when assessing KT candidacy. Although carefully selected KT candidates with low PF can benefit from KT with respect to survival and quality of life, low PF decreases the likelihood of being listed for KT and increases the risk of adverse post-KT outcomes. Recent trials suggest that exercise is a promising strategy to improve PF among KT candidates and recipients.

Summary: PF is a potentially modifiable risk factor for adverse pre- and post-KT outcomes. Research is needed to determine the ideal PF metric for use in KT evaluations and interventions to improve PF.

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肾移植的生理功能:目前的知识和未来的方向。

综述目的:身体功能低下(PF)在终末期肾脏疾病患者中很常见。在这篇综述中，我们探讨了PF对肾移植(KT)和KT结果的影响的数据。我们还讨论了在kt前和kt后改善PF的最新干预措施。最近的发现:许多美国KT项目在评估KT候选资格时测量PF或相关结构。尽管精心挑选的低PF患者可以从生存率和生活质量方面受益于KT，但低PF降低了被列为KT的可能性，并增加了KT后不良结果的风险。最近的试验表明，锻炼是一种有希望改善KT候选人和接受者的PF的策略。总结:PF是一个潜在的可改变的危险因素，可导致不良的kt前后预后。需要研究确定理想的PF指标，用于KT评估和干预措施，以改善PF。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Transplantation Reports Medicine-Surgery

CiteScore

3.40

自引率

4.80%

发文量

期刊介绍： Under the guidance of Dr. Dorry Segev, from Johns Hopkins, Current Transplantation Reports will provide an in-depth review of topics covering kidney, liver, and pancreatic transplantation in addition to immunology and composite allografts.We accomplish this aim by inviting international authorities to contribute review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. By providing clear, insightful balanced contributions, the journal intends to serve those involved in the field of transplantation.