The Role of Quantification of Glucocorticoid-associated Toxicity in Severe Asthma.

P J McDowell, J H Stone, L G Heaney
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Abstract

Until recently, oral glucocorticoid (GC) therapies were the mainstay of treatment for uncontrolled inflammatory disease across many body systems. The last 30 years, however, have witnessed a transformation in the management of many diseases due to the development of targeted biological agents leading to a reduction, albeit not a removal, of the dependence on oral GCs. The need for new glucocorticoid-sparing therapies was urgent given the ever increasing and robust literature on the multisystem adverse effects related to chronic or repeated oral GC exposures [1–6]. The importance of measuring the potential GC-toxicity reduction by “steroid-sparing” agents — and the absence of a validated tool with which to accomplish this goal — was recognised by a group of international investigators from a broad range of medical specialities. These investigators developed and validated such a tool, the Glucocorticoid Toxicity Index (GTI) [7].
糖皮质激素相关毒性在重度哮喘中的定量作用。
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