Joshua K Salabei, Sara Khan, Afzal Khan, Zekarias T Asnake, Troy J Fishman, Jonathan D Stromas, Zeeshan H Ismail, John R Leibach
{"title":"ANCA-Associated Intrahepatic Duct Injury Associated with Levamisole-Adulterated Cocaine.","authors":"Joshua K Salabei, Sara Khan, Afzal Khan, Zekarias T Asnake, Troy J Fishman, Jonathan D Stromas, Zeeshan H Ismail, John R Leibach","doi":"10.1155/2020/8867183","DOIUrl":null,"url":null,"abstract":"<p><p>Damage to the liver or kidney can occur through direct toxic effects; however, damage can also be drug-induced immune-mediated. Levamisole-adulterated cocaine (LAC) is known to cause antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitis and glomerulonephritis leading to acute kidney injury and end-stage renal disease. It remains unclear whether LAC is associated with hepatic duct damage. Here, we report a case with biopsy-proven evidence of intrahepatic duct damage months after being diagnosed with ANCA-associated crescentic and sclerosing glomerulonephritis caused by LAC use. This case represents the first report of LAC-induced ANCA-associated hepatic duct cholestasis in the setting of previous LAC-induced ANCA-positive glomerulonephritis.</p>","PeriodicalId":30295,"journal":{"name":"Case Reports in Hepatology","volume":"2020 ","pages":"8867183"},"PeriodicalIF":0.0000,"publicationDate":"2020-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773451/pdf/","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Case Reports in Hepatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2020/8867183","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
Abstract
Damage to the liver or kidney can occur through direct toxic effects; however, damage can also be drug-induced immune-mediated. Levamisole-adulterated cocaine (LAC) is known to cause antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitis and glomerulonephritis leading to acute kidney injury and end-stage renal disease. It remains unclear whether LAC is associated with hepatic duct damage. Here, we report a case with biopsy-proven evidence of intrahepatic duct damage months after being diagnosed with ANCA-associated crescentic and sclerosing glomerulonephritis caused by LAC use. This case represents the first report of LAC-induced ANCA-associated hepatic duct cholestasis in the setting of previous LAC-induced ANCA-positive glomerulonephritis.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
