Visualization of Lymphatic Vessels Using Photoacoustic Imaging.

IF 1.1 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
KEIO JOURNAL OF MEDICINE Pub Date : 2021-12-25 Epub Date: 2021-01-28 DOI:10.2302/kjm.2020-0010-OA
Hiroki Kajita, Yushi Suzuki, Hisashi Sakuma, Nobuaki Imanishi, Tetsuya Tsuji, Masahiro Jinzaki, Sadakazu Aiso, Kazuo Kishi
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引用次数: 8

Abstract

Lymphedema occurs when interstitial fluid and fibroadipose tissues accumulate abnormally because of decreased drainage of lymphatic fluid as a result of injury, infection, or congenital abnormalities of the lymphatic system drainage pathway. An accurate anatomical map of the lymphatic vasculature is needed not only for understanding the pathophysiology of lymphedema but also for surgical planning. However, because of their limited spatial resolution, no imaging modalities are currently able to noninvasively provide a clear visualization of the lymphatic vessels. Photoacoustic imaging is an emerging medical imaging technique that provides unique scalability of optical resolution and acoustic depth of penetration. Moreover, light-absorbing biomolecules, including oxy- and deoxyhemoglobin, lipids, water, and melanin, can be imaged. Using exogenous contrast agents that are taken up by lymphatic vessels, e.g., indocyanine green, photoacoustic lymphangiography, which has a higher spatial resolution than previous imaging modalities, is possible. Using a new prototype of a photoacoustic imaging system with a wide field of view developed by a Japanese research group, high-resolution three-dimensional structural information of the vasculatures was successfully obtained over a large area in both healthy and lymphedematous extremities. Anatomical information on the lymphatic vessels and adjacent veins provided by photoacoustic lymphangiography is helpful for the management of lymphedema. In particular, such knowledge will facilitate the planning of microsurgical lymphaticovenular anastomoses to bypass the excess fluid component by joining with the circulatory system peripherally. Although challenges remain to establish its implementation in clinical practice, photoacoustic lymphangiography may contribute to improved treatments for lymphedema patients in the near future.

利用光声成像显示淋巴管。
由于损伤、感染或淋巴系统引流通路先天异常导致淋巴液引流减少,导致间质液和纤维脂肪组织异常积聚,发生淋巴水肿。淋巴血管的精确解剖图谱不仅对了解淋巴水肿的病理生理,而且对手术计划也是必要的。然而,由于其有限的空间分辨率,目前没有任何成像方式能够无创地提供淋巴管的清晰可视化。光声成像是一种新兴的医学成像技术,它提供了独特的光学分辨率和声穿透深度的可扩展性。此外,吸收光的生物分子,包括氧和脱氧血红蛋白、脂质、水和黑色素,都可以成像。使用淋巴管吸收的外源性造影剂,如吲哚菁绿,光声淋巴管造影具有比以前成像方式更高的空间分辨率,是可能的。利用日本研究小组开发的具有宽视场的光声成像系统的新原型,成功地获得了健康和淋巴水肿肢体的大面积血管系统的高分辨率三维结构信息。光声淋巴管造影提供的淋巴管和邻近静脉的解剖信息有助于淋巴水肿的治疗。特别是,这些知识将有助于规划显微外科淋巴小静脉吻合术,通过与周围循环系统连接来绕过多余的液体成分。尽管在临床实践中建立其实施仍存在挑战,但在不久的将来,光声淋巴管造影可能有助于改善淋巴水肿患者的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
KEIO JOURNAL OF MEDICINE
KEIO JOURNAL OF MEDICINE MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
3.10
自引率
0.00%
发文量
23
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