Neural support of manual preference revealed by BOLD variations during right and left finger-tapping in a sample of 287 healthy adults balanced for handedness.

IF 0.9 4区 心理学 Q4 PSYCHOLOGY, EXPERIMENTAL
Laterality Pub Date : 2021-07-01 Epub Date: 2021-01-06 DOI:10.1080/1357650X.2020.1862142
N Tzourio-Mazoyer, L Labache, L Zago, I Hesling, B Mazoyer
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引用次数: 9

Abstract

We have identified the brain areas involved in Manual Preference (MP) in 143 left-handers (LH) and 144 right-handers (RH). First, we selected the pairs of homotopic regions of interest (hROIs) of the AICHA atlas with significant contralateral activation and asymmetry during the right hand and the left hand Finger-Tapping (FT) both in RH and LH. Thirteen hROIs were selected, including the primary and secondary sensorimotor and premotor cortices, thalamus, dorsal putamen, and cerebellar lobule IV. In both groups, contralateral activations and ipsilateral deactivations were seen, with stronger asymmetries when the preferred hand was used. Comparing with different models for the prediction of MP, we found that the differences in activity during preferred hand minus non-preferred hand movement in 11 contralateral and/or ipsilateral hROIS were best at explaining handedness distribution. Two different mechanisms were identified: 1. Stronger contralateral activity of cortical and cerebellar motor areas during right hand movement, seen in both groups but modulated by handedness; 2. Stronger deactivation in ipsilateral areas during dominant hand movement in both groups, LH here mirroring RH. The present study thus demonstrates that handedness neural support is complex and not simply based on a mirrored organization of hand motor areas.

287名健康成人右手和左手手指敲击时的BOLD变化揭示了手性偏好的神经支持。
我们确定了143名左撇子(LH)和144名右撇子(RH)参与手动偏好(MP)的大脑区域。首先,我们选择了AICHA图谱中对同位感兴趣区域(hROIs),这些区域在RH和LH的右手和左手手指敲打(FT)时具有显著的对侧激活和不对称性。我们选择了13个hroi,包括初级和次级感觉运动和运动前皮层、丘脑、壳核背侧和小脑IV。在两组中,都观察到对侧激活和同侧失活,当使用首选手时,不对称性更强。通过比较不同的预测模型,我们发现在11个对侧和/或同侧hROIS中,偏好手减去非偏好手运动时的活动差异最能解释手性分布。确定了两种不同的机制:在右手运动时,对侧皮层和小脑运动区活动增强,两组均可见,但受惯用手调节;2. 两组在优势手运动时同侧区域更强的失活,这里的LH反映了RH。因此,目前的研究表明,利手性的神经支持是复杂的,而不是简单地基于一个镜像组织的手运动区域。
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来源期刊
Laterality
Laterality Multiple-
CiteScore
3.60
自引率
7.10%
发文量
26
期刊介绍: Laterality: Asymmetries of Body, Brain and Cognition publishes high quality research on all aspects of lateralisation in humans and non-human species. Laterality"s principal interest is in the psychological, behavioural and neurological correlates of lateralisation. The editors will also consider accessible papers from any discipline which can illuminate the general problems of the evolution of biological and neural asymmetry, papers on the cultural, linguistic, artistic and social consequences of lateral asymmetry, and papers on its historical origins and development. The interests of workers in laterality are typically broad.
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