Combinatorial Strategies for Long-term Control of HIV Infection.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Daekee Kwon, Mi-Jung Han, Kwang-Won Seo, Kyung-Sun Kang
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引用次数: 0

Abstract

AIDS is a disease caused by a chronic infection of HIV. Recently, long-term control of HIV infection has been demonstrated through the bone marrow transplantation of hematopoietic stem cells (HSC), in which the C-C chemokine receptor type 5 (CCR5) gene is mutated innately. However, it is very difficult to obtain CCR5 mutant HSC that match human leukocyte antigen between donor and recipient. To solve this problem, this review will summarize and discuss various reports related to the generation of patient-specific CCR5 geneedited HSC. The fusion of current gene editing (zinc-finger nuclease, transcription activator-like effector nuclease, and clustered regulatory interspaced short palindromic repeats) and cellular reprogramming technology (somatic cell nuclear transfer, induced pluripotent stem cells technology, and direct phenotypic conversion) enables the generation of patient-specific CCR5 edited HSC. These cells can be useful as valuable therapeutic agents for long-term control of HIV-infected patients in the future.

长期控制HIV感染的组合策略。
艾滋病是一种由慢性艾滋病毒感染引起的疾病。最近,通过造血干细胞(HSC)的骨髓移植证明了HIV感染的长期控制,其中C-C趋化因子受体5型(CCR5)基因是先天突变的。然而,在供体和受体之间很难获得匹配人白细胞抗原的CCR5突变HSC。为了解决这一问题,本文将总结和讨论与生成患者特异性CCR5基因编辑HSC相关的各种报道。当前的基因编辑(锌指核酸酶、转录激活因子样效应核酸酶和聚集性调节间隔短回文重复)和细胞重编程技术(体细胞核转移、诱导多能干细胞技术和直接表型转化)的融合,使患者特异性CCR5编辑的HSC得以产生。这些细胞可以作为有价值的治疗剂,在未来长期控制hiv感染患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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