Cardiovascular Risk Factors, Cognitive Dysfunction, and Mild Cognitive Impairment.

IF 1.4 Q4 CLINICAL NEUROLOGY

Dementia and Geriatric Cognitive Disorders Extra Pub Date : 2020-11-16 eCollection Date: 2020-09-01 DOI:10.1159/000511103

Raul Vintimilla, Kishore Balasubramanian, James Hall, Leigh Johnson, Sid O'Bryant

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引用次数: 5

Abstract

Objectives: The present study sought to evaluate the contribution of cardiovascular risk factors to cognitive functioning in a sample of Mexican Americans diagnosed with mild cognitive impairment (MCI).

Methods: Hypertension, diabetes, dyslipidemia, and obesity were diagnosed based on self-report and/or standardized procedures. Cognitive function was measured with MMSE, Logical Memory I and II, Trail A & B, FAS, animal naming, and digit span tests. Independent samples t tests and two-way ANOVAs were conducted for analyses, adjusting for relevant covariates. We studied 100 Mexican Americans (65 female) with MCI, ages 50-86, from a longitudinal study of cognitive aging conducted at the University of North Texas Health Science Center.

Results: A difference between subjects with and without obesity and memory scores was shown by t tests. Two-way ANOVAs detected an association between the coexistence of hypertension and diabetes with language measures, diabetes and dyslipidemia with executive function, and diabetes and obesity with memory and language measures.

Conclusions: This study provides additional evidence about the link between cardiovascular risk factors and cognitive dysfunction in MCI subjects, and also demonstrated that comorbid risk factors increased the degree of cognitive deficit in many areas, which may indicate a higher risk of developing dementia.

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心血管危险因素、认知功能障碍和轻度认知障碍。

目的:本研究旨在评估诊断为轻度认知障碍(MCI)的墨西哥裔美国人样本中心血管危险因素对认知功能的影响。方法:根据自我报告和/或标准化程序诊断高血压、糖尿病、血脂异常和肥胖。通过MMSE、逻辑记忆I和II、Trail A和B、FAS、动物命名和数字广度测试来测量认知功能。采用独立样本t检验和双向方差分析进行分析，并对相关协变量进行调整。我们研究了100名墨西哥裔美国人(65名女性)患有轻度认知障碍，年龄在50-86岁之间，来自北德克萨斯大学健康科学中心进行的认知衰老纵向研究。结果:肥胖和非肥胖受试者之间的差异和记忆得分通过t检验显示。双向方差分析发现高血压和糖尿病共存与语言测量、糖尿病和血脂异常与执行功能、糖尿病和肥胖与记忆和语言测量之间存在关联。结论:本研究为MCI受试者的心血管危险因素与认知功能障碍之间的联系提供了额外的证据，同时也证明了合并症危险因素增加了许多领域的认知缺陷程度，这可能表明发生痴呆的风险更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dementia and Geriatric Cognitive Disorders Extra Medicine-Psychiatry and Mental Health

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

9 weeks

期刊介绍： This open access and online-only journal publishes original articles covering the entire spectrum of cognitive dysfunction such as Alzheimer’s and Parkinson’s disease, Huntington’s chorea and other neurodegenerative diseases. The journal draws from diverse related research disciplines such as psychogeriatrics, neuropsychology, clinical neurology, morphology, physiology, genetic molecular biology, pathology, biochemistry, immunology, pharmacology and pharmaceutics. Strong emphasis is placed on the publication of research findings from animal studies which are complemented by clinical and therapeutic experience to give an overall appreciation of the field. Dementia and Geriatric Cognitive Disorders Extra provides additional contents based on reviewed and accepted submissions to the main journal Dementia and Geriatric Cognitive Disorders Extra .