Judith Díaz-García , Maiken C. Arendrup , Rafael Cantón , Julio García-Rodríguez , Elia Gómez García de la Pedrosa , Gabriella Parisi , Javier Pemán , Brunella Posteraro , Maurizio Sanguinetti , Daniel Archimedes Da Matta , Arnaldo L. Colombo , Patricia Muñoz , Carlos Sánchez-Carrillo , Jesús Guinea , Pilar Escribano
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引用次数: 0
Abstract
Background
The virulence of isolates among different Candida species causing candidemia may play a role in the prognosis of the patients. Furthermore, the potential relationship between genotype and virulence is still unclear and need to be further studied.
Aims
We aim to assess the relationship between genotype and virulence in Candida species using a Galleria mellonella larvae infection model.
Methods
One hundred and ninety-four isolates from 68 clusters (Candida albicans, 114/41; Candida parapsilosis, 74/24; Candida tropicalis, 6/3) were compared against the same number of each species singleton genotypes in terms of survival of G. mellonella larvae.
Results
The median of survival and the IQR ranges of clusters and singleton were as follows: C. albicans (2 days, IQR 1.5–2 vs. 2 days, IQR 1–2.25), C. parapsilosis (2 days, IQR 1.5–2.6 vs. 2 days, IQR 2–3.3), and C. tropicalis (1 day, IQR 1–3.5 vs. 2 days, IQR 2–3.5; p < 0.05). High intra-cluster variability in terms of median of survival was found regardless the species.
Conclusions
No relationship between genotype and virulence in Candida was observed with the G. mellonella model.
期刊介绍:
Revista Iberoamericana de Micología (Ibero-American Journal of Mycology) is the official journal of the Asociación Española de Micología, Asociación Venezolana de Micología and Asociación Argentina de Micología (The Spanish, Venezuelan, and Argentinian Mycology Associations). The Journal gives priority to publishing articles on studies associated with fungi and their pathogenic action on humans and animals, as well as any scientific studies on any aspect of mycology. The Journal also publishes, in Spanish and in English, original articles, reviews, mycology forums, editorials, special articles, notes, and letters to the editor, that have previously gone through a scientific peer review process.