Effects of sulfur dioxide, ozone, and ambient air pollution on bone metabolism related biochemical parameters in a rat model.

Environmental analysis, health and toxicology Pub Date : 2020-12-01 Epub Date: 2020-12-09 DOI:10.5620/eaht.2020023
Sorayya Kheirouri, Mohammad Alizadeh, Razieh Musapour Sultan Abad, Sona Barkabi-Zanjani, Mehran Mesgari-Abbasi
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引用次数: 6

Abstract

Ambient air pollution (AAP), as an important environmental health problem, affects everyone. A large body of literature links AAP, such as sulfur dioxide (SO2) and ozone (O3), with a wide range of non-communicable diseases. The aim of the present study was to investigate the effects of the pollutants on the bone metabolism biochemical parameters in a rat model. Thirty-two male Wistar rats were divided to four groups: control, SO2 (10 ppm), O3 (0.6 ppm), and AAP groups. After 5 weeks of exposure (3 hours/day, 6 days/week), blood samples were taken, and biochemical parameters were assayed. Vitamin D level of the AAP group was higher than the control and SO2 groups (p=0.004 and 0.003). Parathyroid hormone (PTH) level of the O3 group was significantly higher than the AAP group (p=0.006). Alkaline phosphatase (ALP), phosphorus, magnesium levels of the SO2 group; Vit D, ALP, osteocalcin (OC), and PTH of O3 group; and OC and osteoprotegerin (OPG) of AAP group were higher than those of control group but differences were not significant. Calcium level of the SO2 group; OPG and calcium of O3 group; and PTH of AAP group were less than those of control group but differences were not significant (p>0.05). The results showed significant effect of AAP with natural daylight on vitamin D and also O3 on PTH of the rats. In the concentrations and conditions of the study, we didn't find any significant unwanted effects of AAP, SO2, and O3 on the bone biochemical parameters. More investigations with more concentrations and exposure time are recommended.

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二氧化硫、臭氧和环境空气污染对大鼠骨代谢相关生化参数的影响。
环境空气污染作为一个重要的环境健康问题,影响着每一个人。大量文献将二氧化硫(SO2)和臭氧(O3)等AAP与广泛的非传染性疾病联系起来。本研究旨在探讨污染物对大鼠骨代谢生化参数的影响。32只雄性Wistar大鼠分为4组:对照组、SO2 (10ppm)组、O3 (0.6 ppm)组和AAP组。暴露5周(3小时/天,6天/周)后,采集血样,测定生化指标。AAP组维生素D水平高于对照组和SO2组(p=0.004和0.003)。O3组甲状旁腺激素(PTH)水平显著高于AAP组(p=0.006)。SO2组碱性磷酸酶(ALP)、磷、镁水平;O3组Vit D、ALP、骨钙素(OC)、甲状旁腺素(PTH);AAP组OC和骨保护素(OPG)均高于对照组,但差异无统计学意义。SO2组钙水平;OPG和O3基团钙;AAP组患者PTH低于对照组,但差异无统计学意义(p>0.05)。结果显示,AAP配合自然光对大鼠体内维生素D和O3均有显著影响。在本研究的浓度和条件下,我们未发现AAP、SO2和O3对骨生化参数有明显的不良影响。建议进行更多的调查,增加浓度和暴露时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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