Survey of BK Virus in Renal Transplant Recipients in Iran: A Systematic Review and Meta-Analysis.

IF 3.2 4区医学 Q3 VIROLOGY

Intervirology Pub Date : 2020-12-17 DOI:10.1159/000512132

Somayeh Shatizadeh Malekshahi, Hoorieh Soleimanjahi, Fariba Dorostkar, Vahid Salimi, Mohammad Farahmand

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引用次数: 0

Abstract

Introduction: BK virus (BKV) infection in renal transplant (RT) recipients can cause hemorrhagic cystitis, transient renal dysfunction, and BKV nephropathy (BKVN). The prevalence and significance of BKV in RT recipients remain to be clarified in the Iranian population. The purpose of this review is to summarize the overall prevalence of BKV infection in RT recipients from previously published studies in Iran.

Methods: We systematically reviewed articles through a comprehensive search of the main electronic and Persian national databases up to November 2019.

Results: The overall pooled prevalence of BKV infection among the Iranian population was 23% (95% CI; 15-33%). Comparing these studies revealed that the prevalence of BKV in plasma samples ranges from 3 to 40%, in renal biopsies 1-13%, and in urine samples 10-49%. Due to substantial heterogeneity among reported studies (I2 = 93%, p < 0.01), random-effect meta-analysis was performed. BKV infection rate was slightly higher in women than men (16%, p = 0.04 vs. 14%, p < 0.01, respectively). The majority of the studies employed real-time PCR (24%, I2 = 93, p < 0.01) and analyzed plasma samples alone or in combination with other types of specimens. BKV prevalence from 5 cities among the Iranian population showed a higher prevalence rate in Guilan.

Conclusion: Our analysis provides a preliminary estimate of the epidemiology of BKV infection in RT recipients in Iran. These results arouse a need for more epidemiological studies of BKV infection in different unanalyzed regions in Iran. Early detection of BKV in RT recipients helps timely nephropathy diagnosis and prevents graft loss.

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伊朗肾移植受者 BK 病毒调查：系统回顾与元分析》。

导言：肾移植（RT）受者感染 BK 病毒（BKV）可导致出血性膀胱炎、一过性肾功能障碍和 BKV 肾病（BKVN）。在伊朗人群中，BKV 在肾移植受者中的流行率和重要性仍有待明确。本综述旨在总结伊朗以前发表的研究中 RT 受体中 BKV 感染的总体流行率：我们通过对截至 2019 年 11 月的主要电子数据库和波斯国家数据库进行全面检索，对相关文章进行了系统回顾：结果：伊朗人群中 BKV 感染的总体汇总流行率为 23% (95% CI; 15-33%)。比较这些研究发现，BKV 在血浆样本中的感染率为 3% 至 40%，在肾活检样本中的感染率为 1% 至 13%，在尿液样本中的感染率为 10% 至 49%。由于报告的研究之间存在很大的异质性（I2 = 93%，P < 0.01），因此进行了随机效应荟萃分析。女性的 BKV 感染率略高于男性（分别为 16%，P = 0.04 和 14%，P < 0.01）。大多数研究都采用了实时 PCR 技术（24%，I2 = 93，p < 0.01），并对血浆样本进行了单独分析或与其他类型的样本结合分析。伊朗 5 个城市人口中的 BKV 感染率显示，吉兰的感染率较高：我们的分析提供了伊朗 RT 受体中 BKV 感染流行病学的初步估计。这些结果表明，有必要在伊朗不同的未分析地区开展更多的 BKV 感染流行病学研究。早期发现 RT 受体中的 BKV 有助于及时诊断肾病并防止移植物丢失。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Intervirology 医学-病毒学

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Intervirology'' covers progress in both basic and clinical virus research, and aims to provide a forum for the various disciplines within virology. Issues publishing original papers alternate with thematic issues, focusing on clearly defined topics. This thematic concentration serves to make timely reviews, research reports and controversy easily accessible to both specialists in the field and those who want to keep track of the latest developments outside their own area of interest. In addition to original papers, regular issues publish short communications and letters to the editor to provide readers with a forum for the exchange of ideas and comments. The scope encompasses work on the molecular biology of human and animal viruses, including genome organization and regulation, and the structure and function of viral proteins. The pathogenesis, immunology, diagnosis, epidemiology, prophylaxis and therapy of viral diseases are considered.