Differential expression of inflammatory responsive genes between chronic periodontitis and periodontally affected bronchiectasis patients.

IF 1.5 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Biology Research Communications Pub Date : 2020-12-01 DOI:10.22099/mbrc.2020.37397.1508

Abhaya Gupta, Neetu Singh, Anil Kumar, Umesh Pratap Verma, Ajay Kumar Verma, Hari Shyam, Nand Lal, Surya Kant, Ankur Kumari

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引用次数: 1

Abstract

The study aimed to investigate differential expression of targeted inflammatory-immune responsive genes [LTA, LTB, TNFSF4, TNFSF11/RANKL, TNFSF13, TNFSF13B, TNFRSF11B/ Osteoprotegerin; OPG and GFPT1/GFA ] in gingival tissues of bronchiectasis patients having chronic periodontitis in North central Indian population. Gingival tissues were collected from 30 systemically healthy chronic periodontitis patients (CP), 30 bronchiectasis patients with chronic periodontitis (B+CP), 3 systemically healthy with healthy gingiva (healthy control; HC) and 3 bronchiectasis with healthy gingiva (bronchiectasis control; BC). Statistical analysis revealed 7 genes to be significantly upregulated on comparing CP with B+CP i.e LTA (P<0.0001) in B+CP while LTB (P<0.0001), TNFSF4 (P=0.0003), TNFSF11 (P<0.0001), TNFSF13 (P=0.0003), TNFSF13B (P<0.0001) and TNFRSF11B (P=0.0004) in CP group. LTA (Lymphotoxin A) gene could be a potential genetic marker in bronchiectasis patients with chronic periodontitis.

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慢性牙周炎与牙周影响支气管扩张患者炎症反应基因的差异表达。

本研究旨在探讨靶向炎症免疫应答基因[LTA、LTB、TNFSF4、TNFSF11/RANKL、TNFSF13、TNFSF13B、TNFRSF11B/ Osteoprotegerin;印度中北部人群慢性牙周炎支气管扩张患者牙龈组织的OPG和GFPT1/GFA。收集30例全身健康的慢性牙周炎患者(CP)、30例支气管扩张合并慢性牙周炎(B+CP)、3例全身健康且牙龈健康的患者(健康对照组;HC)和3例健康牙龈的支气管扩张(支气管扩张对照组;BC)。经统计学分析，CP组与B+CP组比较，有7个基因显著上调，分别为LTA (PLTB) (PTNFSF4) (P=0.0003)、TNFSF11 (PTNFSF13) (P=0.0003)、TNFSF13B (PTNFRSF11B) (P=0.0004)。LTA(淋巴毒素A)基因可能是支气管扩张合并慢性牙周炎的潜在遗传标记。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Biology Research Communications BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

0.00%

发文量

期刊介绍： “Molecular Biology Research Communications” (MBRC) is an international journal of Molecular Biology. It is published quarterly by Shiraz University (Iran). The MBRC is a fully peer-reviewed journal. The journal welcomes submission of Original articles, Short communications, Invited review articles, and Letters to the Editor which meets the general criteria of significance and scientific excellence in all fields of “Molecular Biology”.