The effectiveness of low-level laser therapy combined with facial expression exercises in patients with moderate-to-severe Bell's palsy: A study protocol for a randomised controlled trial

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2020-01-01 DOI:10.1016/j.isjp.2020.11.001

Praveen Kumar Kandakurti , Sukumar Shanmugam , Shaikh Altaf Basha , Sampath Kumar Amaravadi , Prathap Suganthirababu , Kumaraguruparan Gopal , Geovinson Stephen George

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引用次数: 4

Abstract

Background

Even though corticosteroid therapy and facial expression exercises were found to be effective, still 30% of participants with bell’s palsy achieve incomplete recovery from the facial paralysis. The study objective was to evaluate the effectiveness of low-level laser therapy (LLLT) combined with progressive facial expression exercises in participants with moderate to severe bell’s palsy.

Methodology

A total of 120 participants with idiopathic bell’s palsy to be equally allocated in three groups. LLLT, electrical stimulation and corticosteroid/antiviral therapy will be performed respectively in the group I, group II and Group III and facial expression exercises as a common intervention. First two groups to be treated with respective interventions weekly 3 days for 6 consecutive weeks and third group will receive prescribed doses of medications and facial expression exercise for 6 weeks. The functional recovery will be assessed at baseline, 3 weeks, 6 weeks, and 12 weeks using the Facial Disability Index and House-Brackmann Scale. The overall within and between group differences in the clinical outcomes to be reported based on the Friedman Repeated Measures ANOVA and Kruskal-Wallis test. Whereas Wilcoxon Signed Rank and Mann-Whitney-U tests will be performed to report the within and between groups timeline differences.

Discussion

Based on the dearth of evidence for the effective treatment of moderate to severe bell’s palsy, we framed a most appropriate LLLT dosage along with facial expression exercises. Our study’s intervention protocol designed with equal duration and number of interventions for all three groups. Even the comparator groups such as electrical muscle stimulation and Corticosteroids therapy will be receiving similar facial expression exercises. We believe that this intervention protocol would benefit by promoting the complete facial function recovery in patients with moderate to severe bell’s palsy.

Dissemination

We plan to publish this review in a peer-reviewed journal. We may also present this review at local and/or national conferences.

查看原文本刊更多论文

低水平激光治疗结合面部表情练习对中重度贝尔氏麻痹患者的有效性:一项随机对照试验的研究方案

尽管皮质类固醇治疗和面部表情练习被发现是有效的，但仍有30%的贝尔氏麻痹患者从面瘫中完全恢复。研究目的是评估低水平激光治疗(LLLT)结合渐进式面部表情练习对中度至重度贝尔氏麻痹患者的有效性。方法将120例特发性铃性麻痹患者平均分为三组。在I组、II组和III组分别进行LLLT、电刺激和皮质类固醇/抗病毒治疗，面部表情练习作为常见干预。前两组采用各自的干预措施，每周3天，连续6周;第三组采用规定剂量的药物治疗和面部表情练习，连续6周。使用面部残疾指数和House-Brackmann量表在基线、3周、6周和12周评估功能恢复情况。根据Friedman重复测量方差分析和Kruskal-Wallis检验报告临床结果的组内和组间总体差异。而Wilcoxon sign Rank和Mann-Whitney-U检验将用于报告组内和组间时间线差异。基于缺乏有效治疗中度至重度贝尔氏麻痹的证据，我们制定了最合适的LLLT剂量以及面部表情练习。本研究的干预方案为三组设计了相同的干预时间和数量。即使是比较组，如肌肉电刺激和皮质类固醇治疗，也将接受类似的面部表情练习。我们相信这种干预方案将有利于促进中度至重度贝尔氏麻痹患者面部功能的完全恢复。我们计划在同行评议的期刊上发表这篇综述。我们也可能在地方和/或国家会议上介绍这篇综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.