The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients.

IF 1.7 Q3 UROLOGY & NEPHROLOGY

International Journal of Nephrology Pub Date : 2020-11-09 eCollection Date: 2020-01-01 DOI:10.1155/2020/8893653

Ade Yonata, Zulkhair Ali, Taufik Indrajaya, Erial Bahar, Ian Effendi, Novadian Suhaimi, Suprapti Suprapti

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引用次数: 2

Abstract

Introduction: Chronic kidney disease (CKD) is associated with high mortality rates, mainly as a result of cardiovascular complications. Meanwhile, recent studies have suggested a role of a homodimer protein called activin A in chronic kidney disease-mineral and bone disorder (CKD-MBD) conditions that may exist in the vascular calcification and osteolytic process. Ultrasound examination of the carotid intima-media thickness (cIMT) is a noninvasive method to assess vascular calcification. This study aimed to analyze the relationship between the activin A serum level and cIMT in patients with CKD at Mohammad Hoesin Hospital, Palembang, Indonesia.

Methods: We conducted a hospital-based, cross-sectional study of consecutive CKD patients at the Department of Internal Medicine, Mohammad Hoesin Hospital, from July to November 2019. The level of activin A was measured by enzyme-linked immunosorbent assay. Meanwhile, cIMT measurements were collected by B-mode ultrasound imaging.

Results: A total of 55 patients with CKD were included in this investigation. The median serum activin A level in these patients was 236.17 (116.33-283) pg/mL, while the median cIMT was 0.8 (0.6-1.45) mm. A relationship between the serum activin A level and cIMT (r = 0.449; p = 0.001) was observed. During multivariate analysis with linear regression, triglyceride (p = 0.049), phosphate (p = 0.005), and activin A (p = 0.020) serum levels were factors associated with cIMT.

Conclusion: In this study, a relationship between the activin A serum level and cIMT in patients with CKD was identified. Vascular calcification should be screened for in all CKD patients by the measurement of cIMT.

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慢性肾病患者激活素A血清水平与颈动脉内膜-中膜厚度的关系

慢性肾脏疾病(CKD)与高死亡率相关，主要是由于心血管并发症。与此同时，最近的研究表明，一种称为激活素a的二聚体蛋白在慢性肾脏疾病-矿物质和骨骼疾病(CKD-MBD)中可能存在于血管钙化和溶骨过程中的作用。超声检查颈动脉内膜-中膜厚度(cIMT)是一种评估血管钙化的无创方法。本研究旨在分析印度尼西亚巨港市Mohammad Hoesin医院CKD患者血清激活素A水平与cIMT之间的关系。方法:我们于2019年7月至11月在Mohammad Hoesin医院内科对连续CKD患者进行了一项以医院为基础的横断面研究。酶联免疫吸附法测定活化素A水平。同时，通过b超成像采集cIMT测量值。结果:本研究共纳入55例CKD患者。这些患者的中位血清激活素A水平为236.17 (116.33-283)pg/mL，中位cIMT为0.8 (0.6-1.45)mm。血清激活素A水平与cIMT的关系(r = 0.449;P = 0.001)。在多元线性回归分析中，血清甘油三酯(p = 0.049)、磷酸盐(p = 0.005)和激活素A (p = 0.020)水平是与cIMT相关的因素。结论:本研究确定了CKD患者血清激活素a水平与cIMT之间的关系。在所有CKD患者中，血管钙化应通过测量cIMT进行筛查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Nephrology UROLOGY & NEPHROLOGY-

CiteScore

3.40

自引率

4.80%

发文量

审稿时长

17 weeks

期刊介绍： International Journal of Nephrology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies focusing on the prevention, diagnosis, and management of kidney diseases and associated disorders. The journal welcomes submissions related to cell biology, developmental biology, genetics, immunology, pathology, pathophysiology of renal disease and progression, clinical nephrology, dialysis, and transplantation.