Coinfection of Tuberculosis and HIV in Nigeria: A Systematic Review and Meta-analysis.

IF 1.9 4区 医学 Q4 IMMUNOLOGY
Eleazar E Reward, Anthony C Ike, Sophia O Muo, Busola F Soga-Oke, Emmanuel M Mbaawuaga
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Abstract

Tuberculosis (TB) and HIV/AIDS are major public health issues globally. The burden of these diseases is particularly significant in Nigeria due to the high TB and HIV/AIDS prevalence. This meta-analysis for the 1st time addressed the TB/HIV coinfection prevalence in Nigeria at the regional level. A total of 58 relevant publications comprising 80 studies (n = 44,508) were obtained from PUBMED, ScienceDirect, African Journals Online, and Cochrane Library databases using carefully constructed keywords combinations. The PRISMA guideline was followed for this meta-analysis. Two independent reviewers conducted the publication screening, data extraction and methodological quality appraisal with a third reviewer serving as arbitrator. The pooled estimates were calculated using the random effects model. Heterogeneity was assessed using Cochran's Q and I 2 statistic. Univariate and multivariate meta-regressions were done to predict sources of between-study heterogeneity. Overall, the pooled prevalence of TB/HIV coinfection was 25.8%. The highest coinfection prevalence of 34.3% was recorded among the North Central States of Nigeria, while the least prevalence of 19.3% was recorded among the Southeastern states of Nigeria. There was a paucity of published articles from the Northeastern states of Nigeria. There was a significant heterogeneity between studies (I2 > 90%, p < 0.001), but meta-regression analysis only explained < 10% of it. This study has shown that the prevalence of TB/HIV coinfection remains significantly high in Nigeria. Constant surveillance should be rigorously implemented with special attention given to the Northeast due to the ongoing crises that are compounding the problem.

尼日利亚结核病和艾滋病合并感染:系统综述和荟萃分析。
结核病和艾滋病毒/艾滋病是全球主要的公共卫生问题。由于结核病和艾滋病毒/艾滋病的高流行率,这些疾病的负担在尼日利亚尤为严重。这项荟萃分析首次涉及尼日利亚地区层面的结核病/艾滋病合并感染流行率。使用精心构建的关键词组合,从PUBMED、ScienceDirect、African Journals Online和Cochrane Library数据库共获得58份相关出版物,包括80项研究(n=44508)。本荟萃分析遵循PRISMA指南。两名独立评审员进行了出版物筛选、数据提取和方法学质量评估,第三名评审员担任仲裁员。使用随机效应模型计算合并估计值。使用Cochran的Q和I2统计来评估异质性。进行单变量和多变量元回归来预测研究之间异质性的来源。总体而言,结核病/艾滋病合并感染的总流行率为25.8%。尼日利亚中北部各州的合并感染流行率最高,为34.3%,而尼日利亚东南部各州的最低流行率为19.3%。尼日利亚东北部各州发表的文章很少。研究之间存在显著的异质性(I2>90%,p<0.001),但元回归分析仅解释了<10%。这项研究表明,尼日利亚结核病/艾滋病合并感染的患病率仍然很高。应严格实施持续监测,并特别关注东北部,因为持续的危机加剧了问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
AIDS reviews
AIDS reviews 医学-传染病学
CiteScore
3.40
自引率
4.50%
发文量
41
审稿时长
>12 weeks
期刊介绍: AIDS Reviews publishes papers reporting original scientific, clinical, epidemiologic and social research which contribute to the overall knowledge of the field of the acquired immunodeficiency syndrome and human retrovirology. Currently, the Journal publishes review articles (usually by invitation, but spontaneous submitted articles will also be considered). Manuscripts submitted to AIDS Reviews will be accepted on the understanding that the authors have not submitted the paper to another journal or published the material elsewhere.
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