Effects of Vitamin D on Left Ventricular Ejection Fraction in Patients with Systolic Heart Failure: A Double-Blind Randomized Clinical Trial.

IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM
International Journal of Endocrinology and Metabolism Pub Date : 2020-09-02 eCollection Date: 2020-07-01 DOI:10.5812/ijem.103528
Reza Hassanzadeh-Makoui, Maziar Jamei, Masoud Hassanzadeh-Makoui, Hamid Khederlou
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引用次数: 4

Abstract

Background: Heart failure is a pathophysiologic state in which the cardiac output is not able to supply the body with enough oxygen and nutrients. The prevalence of heart failure has increased dramatically over the last decades. Vitamin D levels in patients with chronic heart failure are lower than healthy controls, and vitamin D deficiency has a direct relationship with mortality.

Objectives: This study aimed to evaluate the effect of vitamin D on the improvement of left ventricular ejection fraction in patients with systolic heart failure.

Methods: In this case-control clinical trial, 142 patients with chronic systolic heart failure were identified. Based on the inclusion and exclusion criteria, 114 patients were enrolled in the study and randomly divided into two groups. One group (n = 58) received 50,000 units of vitamin D capsules weekly for eight weeks, and the patients in the other group (n = 56) received a placebo. After excluding 15 patients from the placebo group and 17 patients from the intervention group during the study, according to the exclusion criteria, 41 patients were evaluated in both groups for ejection fraction changes after two months.

Results: According to the results of this research, there were no statistically significant differences in the baseline parameters between the two studied groups. The intervention group consisted of 18 female and 23 male patients with a mean age of 61.68 ± 19.8 years. Moreover, the placebo group included 21 female and 20 male patients with a mean age of 62.12 ± 18.2 years. After a 2-month follow-up, the intervention group showed statistically significant changes in ejection fraction, end-diastolic volume, and heart failure class compared to the placebo group. Also, the serum level of albumin and vitamin D in the intervention group was significantly higher than the placebo group.

Conclusions: The results of this study show that vitamin D treatment can improve the ejection fraction and functional ability of patients with vitamin D deficiency. If more comprehensive studies support this hypothesis, vitamin D deficiency assessment and correction in patients with chronic heart failure may be recommended.

Abstract Image

维生素D对收缩期心力衰竭患者左心室射血分数的影响:一项双盲随机临床试验
背景:心力衰竭是心输出量不能为机体提供足够的氧气和营养的一种病理生理状态。在过去的几十年里,心力衰竭的发病率急剧上升。慢性心力衰竭患者的维生素D水平低于健康对照组,维生素D缺乏与死亡率有直接关系。目的:本研究旨在评价维生素D对改善收缩期心力衰竭患者左心室射血分数的作用。方法:对142例慢性收缩期心力衰竭患者进行病例对照临床研究。根据纳入和排除标准,114例患者入组,随机分为两组。一组(n = 58)连续八周每周服用50,000单位维生素D胶囊,另一组(n = 56)服用安慰剂。在研究过程中,将安慰剂组15例患者和干预组17例患者排除后,根据排除标准,对两组41例患者在两个月后的射血分数变化进行评估。结果:本研究结果显示,两组患者基线参数差异无统计学意义。干预组患者女性18例,男性23例,平均年龄61.68±19.8岁。此外,安慰剂组包括21名女性和20名男性患者,平均年龄为62.12±18.2岁。经过2个月的随访,与安慰剂组相比,干预组在射血分数、舒张末期容积和心力衰竭等级上有统计学意义的变化。此外,干预组的血清白蛋白和维生素D水平显著高于安慰剂组。结论:本研究结果表明,维生素D治疗可改善维生素D缺乏症患者的射血分数和功能能力。如果更全面的研究支持这一假设,慢性心力衰竭患者的维生素D缺乏评估和纠正可能会被推荐。
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来源期刊
CiteScore
3.10
自引率
4.80%
发文量
0
期刊介绍: The aim of the International Journal of Endocrinology and Metabolism (IJEM) is to increase knowledge, stimulate research in the field of endocrinology, and promote better management of patients with endocrinological disorders. To achieve this goal, the journal publishes original research papers on human, animal and cell culture studies relevant to endocrinology.
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