Preparation of amphiphilic magnetic polyvinyl alcohol targeted drug carrier and drug delivery research.

IF 1.8 4区 化学 Q3 POLYMER SCIENCE
Yazhen Wang, Zhen Shi, Yu Sun, Xueying Wu, Shuang Li, Shaobo Dong, Tianyu Lan
{"title":"Preparation of amphiphilic magnetic polyvinyl alcohol targeted drug carrier and drug delivery research.","authors":"Yazhen Wang,&nbsp;Zhen Shi,&nbsp;Yu Sun,&nbsp;Xueying Wu,&nbsp;Shuang Li,&nbsp;Shaobo Dong,&nbsp;Tianyu Lan","doi":"10.1080/15685551.2020.1837442","DOIUrl":null,"url":null,"abstract":"<p><p>Currently, magnetic applications have great potential for development in the field of drug carriers. In this paper, Fe<sub>3</sub>O<sub>4</sub>-PVA@SH, an amphiphilic magnetically targeting drug carrier, was prepared by using Fe<sub>3</sub>O<sub>4</sub> and PVA with thiohydrazide-iminopropyltriethoxysilane(TIPTS). The loading capacity of Fe<sub>3</sub>O<sub>4</sub>-PVA@SH on Aspirin and the drug release kinetics of loaded drugs were studied. The obtained Fe<sub>3</sub>O<sub>4</sub>-PVA@SH exhibits excellent drug release properties in simulating the human body fluid environment (pH 7.2). Since magnetically targeting drug carriers are readily available and have excellent biocompatibility and the characteristics of drug release. This work's development, preparing amphiphilic magnetically targeting drug carriers in drug delivery and other fields, has great significance.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":"23 1","pages":"197-206"},"PeriodicalIF":1.8000,"publicationDate":"2020-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15685551.2020.1837442","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Designed Monomers and Polymers","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/15685551.2020.1837442","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 7

Abstract

Currently, magnetic applications have great potential for development in the field of drug carriers. In this paper, Fe3O4-PVA@SH, an amphiphilic magnetically targeting drug carrier, was prepared by using Fe3O4 and PVA with thiohydrazide-iminopropyltriethoxysilane(TIPTS). The loading capacity of Fe3O4-PVA@SH on Aspirin and the drug release kinetics of loaded drugs were studied. The obtained Fe3O4-PVA@SH exhibits excellent drug release properties in simulating the human body fluid environment (pH 7.2). Since magnetically targeting drug carriers are readily available and have excellent biocompatibility and the characteristics of drug release. This work's development, preparing amphiphilic magnetically targeting drug carriers in drug delivery and other fields, has great significance.

Abstract Image

Abstract Image

Abstract Image

两亲性磁性聚乙烯醇靶向药物载体的制备及给药研究。
目前,磁性材料在药物载体领域具有很大的发展潜力。本文以Fe3O4和PVA为原料,用硫酰肼-亚氨基丙基三乙氧基硅烷(TIPTS)制备了两亲性磁靶向药物载体Fe3O4-PVA@SH。研究了Fe3O4-PVA@SH对阿司匹林的负载能力和负载药物的释放动力学。所得Fe3O4-PVA@SH在模拟人体体液环境(pH 7.2)中表现出优异的药物释放性能。由于磁性靶向药物载体易于获得,具有良好的生物相容性和药物释放特性。本工作的开展,对制备两亲性磁性靶向药物载体在药物递送等领域具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Designed Monomers and Polymers
Designed Monomers and Polymers 化学-高分子科学
CiteScore
3.30
自引率
0.00%
发文量
28
审稿时长
2.1 months
期刊介绍: Designed Monomers and Polymers ( DMP) publishes prompt peer-reviewed papers and short topical reviews on all areas of macromolecular design and applications. Emphasis is placed on the preparations of new monomers, including characterization and applications. Experiments should be presented in sufficient detail (including specific observations, precautionary notes, use of new materials, techniques, and their possible problems) that they could be reproduced by any researcher wishing to repeat the work. The journal also includes macromolecular design of polymeric materials (such as polymeric biomaterials, biomedical polymers, etc.) with medical applications. DMP provides an interface between organic and polymer chemistries and aims to bridge the gap between monomer synthesis and the design of new polymers. Submssions are invited in the areas including, but not limited to: -macromolecular science, initiators, macroinitiators for macromolecular design -kinetics, mechanism and modelling aspects of polymerization -new methods of synthesis of known monomers -new monomers (must show evidence for polymerization, e.g. polycondensation, sequential combination, oxidative coupling, radiation, plasma polymerization) -functional prepolymers of various architectures such as hyperbranched polymers, telechelic polymers, macromonomers, or dendrimers -new polymeric materials with biomedical applications
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信