Influence of near-wall PIV data on recirculation hemodynamics in a patient-specific moderate stenosis: Experimental-numerical comparison.

IF 1 4区医学 Q4 BIOPHYSICS

Biorheology Pub Date : 2020-01-01 DOI:10.3233/BIR-201001

Neha Sharma, Sudeep Sastry, John M Sankovic, Jaikrishnan R Kadambi, Rupak K Banerjee

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引用次数: 1

Abstract

Background: Recirculation zones within the blood vessels are known to influence the initiation and progression of atherosclerotic lesions. Quantification of recirculation parameters with accuracy remains subjective due to uncertainties in measurement of velocity and derived wall shear stress (WSS).

Objective: The primary aim is to determine recirculation height and length from PIV experiments while validating with two different numerical methods: finite-element (FE) and -volume (FV). Secondary aim is to analyze how FE and FV compare within themselves.

Methods: PIV measurements were performed to obtain velocity profiles at eight cross sections downstream of stenosis at flow rate of 200 ml/min. WSS was obtained by linear/quadratic interpolation of experimental velocity measurements close to wall.

Results: Recirculation length obtained from PIV technique was 1.47 cm and was within 2.2% of previously reported in-vitro measurements. Derived recirculation length from PIV agreed within 6.8% and 8.2% of the FE and FV calculations, respectively. For lower shear rate, linear interpolation with five data points results in least error. For higher shear rate either higher order (quadratic) interpolation with five data points or lower order (linear) with lesser (three) data points leads to better results.

Conclusion: Accuracy of the recirculation parameters is dependent on number of near wall PIV data points and the type of interpolation algorithm used.

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近壁PIV数据对患者特异性中度狭窄再循环血流动力学的影响:实验-数值比较。

背景:已知血管内的再循环区影响动脉粥样硬化病变的发生和进展。由于测量速度和导出的壁面剪切应力(WSS)的不确定性，精确的再循环参数量化仍然是主观的。目的:主要目的是通过PIV实验确定再循环的高度和长度，并通过两种不同的数值方法进行验证:有限元(FE)和体积(FV)。第二个目的是分析FE和FV之间的比较。方法:在流速为200 ml/min时，用PIV测量狭窄下游8个横截面的流速分布图。WSS是通过对近壁实验速度测量值进行线性/二次插值得到的。结果:PIV技术获得的再循环长度为1.47 cm，与先前报道的体外测量值相比在2.2%以内。从PIV中得到的再循环长度分别在FE和FV计算值的6.8%和8.2%范围内一致。对于较低的剪切速率，5个数据点的线性插值结果误差最小。对于更高的剪切速率，高阶(二次)插值与五个数据点或低阶(线性)插值较少(三个)数据点导致更好的结果。结论:再循环参数的准确性取决于近壁PIV数据点的数量和所使用的插值算法的类型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biorheology 医学-工程：生物医学

CiteScore

2.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Biorheology is an international interdisciplinary journal that publishes research on the deformation and flow properties of biological systems or materials. It is the aim of the editors and publishers of Biorheology to bring together contributions from those working in various fields of biorheological research from all over the world. A diverse editorial board with broad international representation provides guidance and expertise in wide-ranging applications of rheological methods to biological systems and materials. The scope of papers solicited by Biorheology extends to systems at different levels of organization that have never been studied before, or, if studied previously, have either never been analyzed in terms of their rheological properties or have not been studied from the point of view of the rheological matching between their structural and functional properties. This biorheological approach applies in particular to molecular studies where changes of physical properties and conformation are investigated without reference to how the process actually takes place, how the forces generated are matched to the properties of the structures and environment concerned, proper time scales, or what structures or strength of structures are required.