Prospects for the application of growth factors in wound healing.

IF 1.8 4区 生物学 Q4 CELL BIOLOGY
Growth factors Pub Date : 2020-01-01 Epub Date: 2020-11-05 DOI:10.1080/08977194.2020.1820499
Sanam Dolati, Mehdi Yousefi, Alireza Pishgahi, Salman Nourbakhsh, Behzad Pourabbas, Seyed Kazem Shakouri
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引用次数: 12

Abstract

As the largest organ of the body, human skin is multifunctional and enjoys two layers, the epidermis and the dermis, the separation of which is performed by a basement membrane zone. Skin protects the body against mechanical forces and infections. Skin wounds represent large and growing challenges to the healthcare systems globally. Skin wound healing, as a protective shield for the body against the external environment, includes interactions among cell types, the neurovascular system, cytokines, and matrix remodeling. Growth factors (GFs) affect the microenvironment of the wound, and cause rises in cell differentiation, proliferation, and migration. Administrating exogenous GFs has revealed potential in enhancing wound healing outcomes. The use of human GFs in the field of wound healing is becoming gradually more interesting, because of the low-invasive techniques required for their use. Reviewed here are the literatures on the healing of skin wounds with emphasize on the role of GFs and their future prospects, containing profits, and probable long-standing side effects accompanied with their use.

生长因子在伤口愈合中的应用前景。
人体皮肤是人体最大的器官,具有多种功能,分为表皮和真皮层两层,真皮和表皮由基底膜区分离。皮肤保护身体免受机械力和感染。皮肤伤口对全球卫生保健系统构成了巨大且日益严峻的挑战。皮肤创面愈合作为机体抵御外界环境的屏障,包括细胞类型、神经血管系统、细胞因子和基质重塑之间的相互作用。生长因子(GFs)影响伤口的微环境,引起细胞分化、增殖和迁移的增加。外源性GFs已显示出增强伤口愈合结果的潜力。由于其使用所需的低侵入性技术,人类GFs在伤口愈合领域的应用正逐渐变得越来越有趣。本文综述了关于皮肤伤口愈合的文献,重点介绍了gf的作用和它们的未来前景,包括益处,以及伴随它们使用的可能的长期副作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Growth factors
Growth factors 生物-内分泌学与代谢
CiteScore
2.60
自引率
0.00%
发文量
20
审稿时长
>12 weeks
期刊介绍: Growth Factors is an international and interdisciplinary vehicle publishing new knowledge and findings on the regulators of cell proliferation, differentiation and survival. The Journal will publish research papers, short communications and reviews on current developments in cell biology, biochemistry, physiology or pharmacology of growth factors, cytokines or hormones which improve our understanding of biology or medicine. Among the various fields of study topics of particular interest include: •Stem cell biology •Growth factor physiology •Structure-activity relationships •Drug development studies •Clinical applications
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