Pathogenesis guided therapeutic management of COVID-19: an immunological perspective.

IF 4.3 4区医学 Q2 IMMUNOLOGY

International Reviews of Immunology Pub Date : 2021-01-01 Epub Date: 2020-10-28 DOI:10.1080/08830185.2020.1840566

Ashutosh Kumar, Pranav Prasoon, Prakash S Sekhawat, Vikas Pareek, Muneeb A Faiq, Chiman Kumari, Ravi K Narayan, Maheswari Kulandhasamy, Kamla Kant

引用次数: 11

Abstract

Lack of standardized therapeutic approaches is arguably the significant contributor to the high burden of mortality observed in the ongoing pandemic of the Coronavirus disease, 2019 (COVID-19). Evidence is accumulating on SARS-CoV-2 specific immune cell dysregulation and consequent tissue injury in COVID-19. Currently, no definite drugs or vaccines are available against the disease; however initial results of the ongoing clinical trials have raised some hope. In this article, taking insights from the emerging empirical evidence about host-virus interactions, we deliberate upon plausible pathogenic mechanisms and suitable therapeutic approaches for COVID-19.

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新冠肺炎发病机制指导下的治疗管理:免疫学视角

缺乏标准化的治疗方法可以说是导致2019年冠状病毒病(COVID-19)大流行中观察到的高死亡率负担的重要因素。关于COVID-19中SARS-CoV-2特异性免疫细胞失调和随之而来的组织损伤的证据越来越多。目前，尚无针对该疾病的明确药物或疫苗;然而，正在进行的临床试验的初步结果带来了一些希望。在本文中，根据新出现的关于宿主-病毒相互作用的经验证据，我们探讨了COVID-19的合理致病机制和合适的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Reviews of Immunology 医学-免疫学

CiteScore

11.00

自引率

4.00%

发文量

期刊介绍： This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).