Use of Prostate Systematic and Targeted Biopsy on the Basis of Bi-Parametric Magnetic Resonance Imaging in Biopsy-Naïve Patients.

Yifei Cheng, Feng Qi, Linghui Liang, Lei Zhang, Dongliang Cao, Lixin Hua, Gong Cheng
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引用次数: 3

Abstract

Objectives: To explore the performance of targeted biopsy (TB) in combination with systematic biopsy (SB) in the detection of prostate cancer (PCa) in biopsy naïve patients.

Methods: From May 2018 to January 2020, 230 biopsy-naïve men with suspicious bi-parametric MRI [bpMRI; Prostate Imaging Reporting and Data System (PI-RADS) score ≥3] were enrolled. All patients had prostate-specific antigen (PSA) levels of 20 ng/ml or less. For each patient, transrectal ultrasound-guided prostate biopsy was performed. The primary endpoint was the detection rate of CSPC [clinically-significant PCa, International Society of Urological Pathology grade group (ISUP GG) 2 or higher tumors]. The secondary endpoints were the detection rates of CIPC (clinically insignificant PCa, ISUP GG 1 tumors).

Results: CSPC was detected in 90 patients. Twelve (13.33%) of them were detected by TB only and 18 (20.00%) by SB only. Detection of CSPC by SB and TB did not differ significantly (p = .36). In 4.35% of 230 patients, CSPC would have been missed if we performed SB only, and in 6.09% of patients if we performed TB only. Moreover, combination of TB and SB did not increase the detection of CIPC.

Conclusions: No significant difference was found in the detection of CSPC between TB and SB; however, both techniques revealed substantial added value and combination of TB and SB could further improve this detection rate without increasing the detection of CIPC.

基于双参数磁共振成像在Biopsy-Naïve患者中前列腺系统和靶向活检的应用。
目的:探讨靶向活检(TB)联合系统活检(SB)在活检naïve患者前列腺癌(PCa)检测中的应用价值。方法:2018年5月至2020年1月,230例biopsy-naïve双参数MRI可疑男性[bpMRI;前列腺影像学报告和数据系统(PI-RADS)评分≥3分]。所有患者的前列腺特异性抗原(PSA)水平为20 ng/ml或更低。对每位患者进行经直肠超声引导下的前列腺活检。主要终点为CSPC(临床显著性PCa,国际泌尿病理学学会分级组(ISUP GG) 2级及以上肿瘤)的检出率。次要终点为CIPC(临床不显著的PCa, ISUP GG 1肿瘤)的检出率。结果:90例患者中检出CSPC。其中仅TB检出12例(13.33%),单SB检出18例(20.00%)。SB和TB对CSPC的检测差异无统计学意义(p = 0.36)。在230例患者中,如果我们只做SB检查,4.35%的患者会遗漏CSPC,如果我们只做TB检查,6.09%的患者会遗漏CSPC。此外,TB与SB合用并未增加CIPC的检出率。结论:TB与SB血清CSPC检测无显著性差异;然而,这两种技术都显示出很大的附加价值,并且TB和SB结合可以在不增加CIPC检出率的情况下进一步提高这一检出率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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