Crocetin Alleviates Inflammation in MPTP-Induced Parkinson's Disease Models through Improving Mitochondrial Functions.

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Parkinson's Disease Pub Date : 2020-10-10 eCollection Date: 2020-01-01 DOI:10.1155/2020/9864370

Na Dong, Zhong Dong, Ying Chen, Xiaosu Gu

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引用次数: 9

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disease. Crocetin, derived from saffron, exerts multiple pharmacological properties, such as anti-inflammatory, antioxidant, antifatigue, and anticancer effects. However, the effect of crocetin on PD remains unclear. In this study, we designed experiments to investigate the effect of crocetin against MPTP-induced PD models and the underlying mechanisms. Our results showed that crocetin treatment attenuates MPTP-induced motor deficits and protects dopaminergic neurons. Both in vivo and in vitro experiments demonstrated that crocetin treatment decreased the expression of inflammatory associated genes and inflammatory cytokines. Furthermore, crocetin treatment protected mitochondrial functions against MPP+ induced damage by regulating the mPTP (mitochondrial permeability transition pore) viability in the interaction of ANT (adenine nucleotide translocase) and Cyp D (Cyclophilin D) dependent manner. Therefore, our results demonstrate that crocetin has therapeutic potential in Parkinson's disease.

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Crocetin通过改善线粒体功能减轻mptp诱导的帕金森病模型的炎症

帕金森病(PD)是第二常见的神经退行性疾病。从藏红花中提取的藏红花素具有多种药理特性，如抗炎、抗氧化、抗疲劳和抗癌作用。然而，crocetin对PD的影响尚不清楚。在本研究中，我们设计了实验来研究crocetin对mptp诱导的PD模型的影响及其潜在机制。我们的研究结果表明，crocetin治疗可以减轻mptp诱导的运动缺陷，并保护多巴胺能神经元。体内和体外实验均表明，crocetin治疗可降低炎症相关基因和炎症细胞因子的表达。此外，在腺嘌呤核苷酸转位酶(ANT)和亲环蛋白D (Cyp D)依赖的相互作用中，crocetin通过调节mPTP(线粒体通透性过渡孔)活力，保护线粒体功能免受MPP+诱导的损伤。因此，我们的研究结果表明crocetin在帕金森病中具有治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Parkinson's Disease CLINICAL NEUROLOGY-

CiteScore

5.80

自引率

3.10%

发文量

审稿时长

18 weeks

期刊介绍： Parkinson’s Disease is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the epidemiology, etiology, pathogenesis, genetics, cellular, molecular and neurophysiology, as well as the diagnosis and treatment of Parkinson’s disease.