MicroRNA-203 inhibits epithelial-mesenchymal transition, migration, and invasion of renal cell carcinoma cells via the inactivation of the PI3K/AKT signaling pathway by inhibiting CAV1.

IF 3.3 3区 生物学 Q3 CELL BIOLOGY
Ning Han, Hai Li, Hui Wang
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引用次数: 9

Abstract

The present study aimed to evaluate the underlying mechanism of microRNA-203 (miR-203) in renal cell carcinoma (RCC) involving the PI3K/AKT signaling pathway. The results revealed downregulated miR-203 and upregulated CAV1 in RCC tissues. Upregulated miR-203 and downregulated CAV1 increased E-cadherin expression and cell apoptosis, decreased β-catenin and N-cadherin expression and cell proliferation, migration and invasion, and blocked cell cycle entry. CAV1, a target gene of miR-203, decreased by up-regulated miR-203, and silencing CAV1 led to the inactivation of PI3K/AKT signaling pathway. In conclusion, our findings suggested that miR-203-mediated direct suppression of CAV1 inhibits EMT of RCC cells via inactivation of the PI3K/AKT signaling pathway.

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MicroRNA-203通过抑制CAV1,使PI3K/AKT信号通路失活,从而抑制肾癌细胞的上皮-间质转化、迁移和侵袭。
本研究旨在探讨microRNA-203 (miR-203)在肾细胞癌(RCC)中参与PI3K/AKT信号通路的潜在机制。结果显示,在RCC组织中miR-203下调,CAV1上调。miR-203上调,CAV1下调,E-cadherin表达增加,细胞凋亡增加,β-catenin、N-cadherin表达减少,细胞增殖、迁移、侵袭减少,细胞周期进入受阻。miR-203的靶基因CAV1因miR-203上调而降低,沉默CAV1导致PI3K/AKT信号通路失活。总之,我们的研究结果表明,mir -203介导的直接抑制CAV1通过使PI3K/AKT信号通路失活来抑制RCC细胞的EMT。
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来源期刊
CiteScore
6.40
自引率
0.00%
发文量
7
审稿时长
53 weeks
期刊介绍: Cell Adhesion & Migration is a multi-disciplinary, peer reviewed open access journal that focuses on the biological or pathological implications of cell-cell and cell-microenvironment interactions. The main focus of this journal is fundamental science. The journal strives to serve a broad readership by regularly publishing review articles covering specific disciplines within the field, and by publishing focused issues that provide an overview on specific topics of interest within the field. Cell Adhesion & Migration publishes relevant and timely original research, as well as authoritative overviews, commentaries, and perspectives, providing context for the work presented in Cell Adhesion & Migration and for key results published elsewhere. Original research papers may cover all topics important in the field of cell-cell and cell-matrix interactions. Cell Adhesion & Migration also publishes articles related to cell biomechanics, biomaterial, and development of related imaging technologies.
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