Roles of Regulatory RNAs in Nutritional Control.

IF 12.6 2区 医学 Q1 NUTRITION & DIETETICS
Elizabeth M McNeill, Kendal D Hirschi
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引用次数: 4

Abstract

Small RNAs (sRNAs), including microRNAs (miRNAs), are noncoding RNA (ncRNA) molecules involved in gene regulation. sRNAs play important roles in development; however, their significance in nutritional control and as metabolic modulators is still emerging. The mechanisms by which diet impacts metabolic genes through miRNAs remain an important area of inquiry. Recent work has established how miRNAs are transported in body fluids often within exosomes, which are small cell-derived vesicles that function in intercellular communication. The abundance of other recently identified ncRNAs and new insights regarding ncRNAs as dietary bioactive compounds could remodel our understanding about how foods impact gene expression. Although controversial, some groups have shown that dietary RNAs from plants and animals (i.e., milk) are functional in consumers. In the future, regulating sRNAs either directly through dietary delivery or indirectly by altered expression of endogenous sRNA may be part of nutritional interventions for regulating metabolism.

调控rna在营养控制中的作用。
小RNA (Small RNA, sRNAs),包括microRNAs (miRNAs),是参与基因调控的非编码RNA (ncRNA)分子。sRNAs在发育过程中发挥重要作用;然而,它们在营养控制和代谢调节剂方面的意义仍在逐渐显现。饮食通过mirna影响代谢基因的机制仍然是一个重要的研究领域。最近的工作已经确定了mirna如何在体液中通常在外泌体内运输,外泌体是细胞来源的小泡,在细胞间通讯中起作用。最近发现的大量其他ncrna以及关于ncrna作为膳食生物活性化合物的新见解可以重塑我们对食物如何影响基因表达的理解。尽管存在争议,但一些研究小组已经表明,来自植物和动物(即牛奶)的膳食rna在消费者体内是有功能的。在未来,通过饮食直接或通过改变内源性sRNA的表达间接调节sRNA可能是调节代谢的营养干预的一部分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annual review of nutrition
Annual review of nutrition 医学-营养学
CiteScore
15.80
自引率
0.00%
发文量
19
期刊介绍: Annual Review of Nutrition Publication History:In publication since 1981 Scope:Covers significant developments in the field of nutrition Topics Covered Include: Energy metabolism; Carbohydrates; Lipids; Proteins and amino acids; Vitamins; Minerals; Nutrient transport and function; Metabolic regulation; Nutritional genomics; Molecular and cell biology; Clinical nutrition; Comparative nutrition; Nutritional anthropology; Nutritional toxicology; Nutritional microbiology; Epidemiology; Public health nutrition
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