Elevated Serum Ceruloplasmin Levels Are Associated with Higher Impulsivity in People with Parkinson's Disease.

IF 2.1 4区 医学 Q3 CLINICAL NEUROLOGY
Parkinson's Disease Pub Date : 2020-09-30 eCollection Date: 2020-01-01 DOI:10.1155/2020/8296203
Megan C Bakeberg, Maddeson Riley, Michelle Byrnes, Alexa Jefferson, Souyma Ghosh, Malcom K Horne, Sarah McGregor, Rick Stell, Sue Walters, Tess Evans, Katherine Roberts, Frank L Mastaglia, Ryan S Anderton
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引用次数: 0

Abstract

Background: Heightened impulsivity has been reported in a subset of people with Parkinson's disease (PwP) and is considered a risk factor for the development of impulse control disorders (ICDs). However, at present, there are no recognised biochemical markers of heightened impulsivity.

Objectives: To determine if ceruloplasmin, a serum marker involved in the regulation of iron and copper homeostasis, is associated with trait impulsivity in PwP.

Methods: The study measured serum ceruloplasmin and impulsivity using the Barratt Impulsiveness Scale (BIS-11) in an Australian cohort of 214 PwP. Multivariate general linear models (GLMs) were used to identify whether higher serum ceruloplasmin levels (>75th percentile) were significantly predictive of BIS-11 scores.

Results: Serum ceruloplasmin was higher in females with PD (p < 0.001) and associated with MDS-UPDRS III, Hoehn and Yahr, and ACE-R scores (p < 0.05). When correcting for covariates, higher serum ceruloplasmin concentrations were associated with the 2nd order nonplanning impulsivity and with the 1st order self-control and cognitive complexity impulsivity domains.

Conclusions: Higher serum ceruloplasmin levels are independently associated with heightened nonplanning impulsivity in PwP. Thus, serum ceruloplasmin levels may have clinical utility as a marker for heightened impulsivity in PD.

帕金森病患者血清脑磷脂水平升高与冲动性增高有关。
背景:据报道,帕金森病(PwP)患者中有一部分人冲动性增高,这被认为是冲动控制障碍(ICD)发病的一个危险因素。然而,目前还没有公认的冲动性增强的生化标志物:目的:确定参与铁和铜平衡调节的血清标志物脑磷脂是否与 PwP 的特质冲动有关:该研究使用巴拉特冲动性量表(BIS-11)测量了澳大利亚 214 名儿童患者队列中的血清脑磷脂和冲动性。研究采用多变量一般线性模型(GLMs)来确定血清脑磷脂水平越高(>第 75 百分位数)是否对 BIS-11 评分有显著的预测作用:患有帕金森病的女性血清脑磷脂水平较高(p < 0.001),且与MDS-UPDRS III、Hoehn and Yahr和ACE-R评分相关(p < 0.05)。校正协变量后,较高的血清脑磷脂浓度与二阶非计划冲动以及一阶自我控制和认知复杂性冲动相关:结论:较高的血清脑磷脂水平与 PwP 中较高的非计划冲动性独立相关。因此,血清脑磷脂水平可作为帕金森病冲动性增强的临床标记物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Parkinson's Disease
Parkinson's Disease CLINICAL NEUROLOGY-
CiteScore
5.80
自引率
3.10%
发文量
0
审稿时长
18 weeks
期刊介绍: Parkinson’s Disease is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the epidemiology, etiology, pathogenesis, genetics, cellular, molecular and neurophysiology, as well as the diagnosis and treatment of Parkinson’s disease.
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