Parkinson's Disease-Related Risk of Suicide and Effect of Deep Brain Stimulation: Meta-Analysis.

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Parkinson's Disease Pub Date : 2020-09-27 eCollection Date: 2020-01-01 DOI:10.1155/2020/8091963

Juncong Du, Xi Liu, Xuan Zhou, Hui Wang, Wen Zhou, Jin Jiang, Wuxue Peng, Lijuan Mo, Changhong Tan, Lifen Chen

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引用次数: 8

Abstract

Background: Previous studies investigated the risk of suicide in patients with Parkinson's disease (PD) but reported discrepant results. Deep brain stimulation (DBS) is an effective therapy for PD, while its effect on suicide risk has seldom been researched. This meta-analysis aimed to estimate the risk of suicide and/or suicidal ideation in PD patients and in PD patients who underwent DBS.

Methods: Relevant articles published in the PubMed or EMBASE or CNKI database from 1990 to December 2019 were sourced, and the combined standardized mortality rate (SMR) or odds ratio (OR) was pooled.

Result: A total of 1070 articles were found. After screening, 4 cross-sectional studies, 4 cohort studies, 2 randomized controlled trial studies, and 2 case-control studies were included in this meta-analysis. Pooled data indicated that PD patients may have increased risk of suicide (lnSMR, 0.459; 95% confidence interval (CI), 0.286 to 0.632; p < 0.001). No significant difference was found in the risk of suicide when comparing PD patients who underwent DBS with PD patients who received only drug therapy (OR = 2.844, 95%CI: 0.619 to 13.072, p=0.179). DBS may increase the risk of suicide and/or suicidal ideation in PD patients compared with general population (lnSMR = 3.383, 95%CI: 2.839 to 3.927, p < 0.001).

Conclusion: PD patients have higher risk of suicide and/or suicidal ideation compared with controls, while PD patients who received DBS tend to have an increased risk of suicide or suicidal ideation. Psychological evaluation is needed in PD patients, and pre- and post-operation evaluations are necessary for PD patients who underwent DBS.

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帕金森病相关自杀风险及脑深部刺激效果:meta分析

背景:以前的研究调查了帕金森病(PD)患者的自杀风险，但报告的结果不一致。脑深部电刺激(DBS)是治疗帕金森病的有效方法，但其对自杀风险的影响研究甚少。本荟萃分析旨在评估PD患者和接受DBS的PD患者的自杀和/或自杀意念的风险。方法:检索1990年至2019年12月PubMed、EMBASE或CNKI数据库中发表的相关文献，汇总其综合标准化死亡率(SMR)或优势比(or)。结果:共检索到1070篇文献。筛选后纳入4项横断面研究、4项队列研究、2项随机对照试验和2项病例对照研究。汇总数据显示，PD患者自杀风险可能增加(lnSMR, 0.459;95%置信区间(CI)为0.286 ~ 0.632;P < 0.001)。与仅接受药物治疗的PD患者相比，接受DBS治疗的PD患者自杀风险无显著差异(OR = 2.844, 95%CI: 0.619 ~ 13.072, p=0.179)。与一般人群相比，DBS可能增加PD患者自杀和/或自杀意念的风险(lnSMR = 3.383, 95%CI: 2.839 ~ 3.927, p < 0.001)。结论:与对照组相比，PD患者有更高的自杀和/或自杀意念的风险，而接受DBS治疗的PD患者有更高的自杀或自杀意念的风险。PD患者需要进行心理评估，对DBS患者进行术前和术后评估是必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Parkinson's Disease CLINICAL NEUROLOGY-

CiteScore

5.80

自引率

3.10%

发文量

审稿时长

18 weeks

期刊介绍： Parkinson’s Disease is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the epidemiology, etiology, pathogenesis, genetics, cellular, molecular and neurophysiology, as well as the diagnosis and treatment of Parkinson’s disease.