A Comprehensive Study of Dengue Epidemics and Persistence of Anti-Dengue Virus Antibodies in District Swat, Pakistan.

IF 3.2 4区医学 Q3 VIROLOGY

Intervirology Pub Date : 2020-01-01 Epub Date: 2020-10-13 DOI:10.1159/000510347

Naveed Ahmad, Tariq Khan, Syed Muhammad Jamal

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引用次数: 5

Abstract

Background: Dengue fever is one of the most common human arbovirus infections worldwide. In Pakistan, dengue initially became endemic in the big cities and then expanded to remote areas of the country. The current study reports the dengue epidemics, anti-DENV antibodies prevalence during the active and post-dengue infection, risk factors, disease symptoms, and spotting dengue infection densities in district Swat of Pakistan.

Methods: Clinical signs and demographic data of dengue suspected individuals were collected at the time of screening through non-structural protein-1 antigen detection test during 2013-2015. Moreover, selected dengue confirmed individuals were screened for the presence of anti-dengue immunoglobulin (Ig) M and G during the active infection period and post-dengue infection.

Results: A total of 8,770 individuals were infected with dengue in 2013 with 36 (0.41%) case fatalities, 307 in 2014 with no case fatality, and 13 in 2015 with no case fatality. The number of male and female cases were 6,139 and 2,631 in 2013, 183 and 124 in 2014, and only 10 and 3 in 2015, respectively. Among all the localities, Tehsil Babozai, an urban setting, reported the highest number of dengue patients during all the study years, that is, 7,673 (87.49% of the total cases) in 2013, 294 (95.76% of the total cases) in 2014, and 13 (100% cases) in 2015. Among 6 age groups, 21-30 years was found to be highly infected in 2013 (37.13% of all cases) and 2014 (33.55%). Furthermore, 1,231 (21.94% of all cases) had IgM antibodies and 71 (1.26%) had IgG antibodies in 2013, 78 (26% of all cases) had IgM antibodies and 7 (2.33%) had IgG antibodies in 2014, and only 4 (30.76%) patients had IgM and 0 (0%) had IgG antibodies in 2015. Furthermore, urban areas had the highest infection density in district Swat. The majority of the patients in rural areas had a traveling history to the urban areas before their illness.

Conclusion: To sum up, male gender, young individuals, and those living in urban areas were at the greater risk of dengue infection.

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巴基斯坦斯瓦特地区登革热流行和抗登革热病毒抗体持久性的综合研究。

背景:登革热是世界范围内最常见的人类虫媒病毒感染之一。在巴基斯坦，登革热最初在大城市流行，然后扩展到该国的偏远地区。本研究报告了巴基斯坦斯瓦特地区登革热流行情况、登革热活动性感染和登革热感染后的抗denv抗体流行情况、危险因素、疾病症状和登革热感染密度。方法:通过非结构蛋白-1抗原检测试验收集2013-2015年登革热疑似病例筛查时的临床体征和人口统计学资料。此外，筛选登革热确诊个体在感染活跃期和感染后的抗登革热免疫球蛋白(Ig) M和G的存在。结果:2013年共发生登革热病例8770例，死亡36例(0.41%)，2014年307例(无死亡)，2015年13例(无死亡)。2013年男性6139例，女性2631例，2014年183例，女性124例，2015年仅10例，女性3例。所有地区中，城市巴博扎伊市报告登革热病例最多，2013年为7673例(占总病例数的87.49%)，2014年为294例(占总病例数的95.76%)，2015年为13例(100%)。在6个年龄组中，2013年和2014年21-30岁为高发人群(占全部病例的37.13%)和33.55%。2013年有IgM抗体1231例(21.94%)，IgG抗体71例(1.26%)，2014年有IgM抗体78例(26%)，IgG抗体7例(2.33%)，2015年有IgM抗体4例(30.76%)，IgG抗体0例(0%)。此外，城市地区感染密度最高的是斯瓦特区。多数农村地区患者发病前有城市旅行史。结论:总体而言，男性、年轻人和城市人群是登革热感染的高危人群。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Intervirology 医学-病毒学

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Intervirology'' covers progress in both basic and clinical virus research, and aims to provide a forum for the various disciplines within virology. Issues publishing original papers alternate with thematic issues, focusing on clearly defined topics. This thematic concentration serves to make timely reviews, research reports and controversy easily accessible to both specialists in the field and those who want to keep track of the latest developments outside their own area of interest. In addition to original papers, regular issues publish short communications and letters to the editor to provide readers with a forum for the exchange of ideas and comments. The scope encompasses work on the molecular biology of human and animal viruses, including genome organization and regulation, and the structure and function of viral proteins. The pathogenesis, immunology, diagnosis, epidemiology, prophylaxis and therapy of viral diseases are considered.