A Reliable Tool for Assessing MCI and Dementia: Validation Study of DemTect for Turkish Population.

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2020-01-01 DOI:10.1177/1533317520949805

Gozde Sengul Aycicek, Hatice Çalıskan, Cemile Ozsurekci, Pelin Unsal, Josef Kessler, E Kalbe, Mert Esme, Rana Tuna Dogrul, Cafer Balcı, Umran Seven, Erdem Karabulut, Meltem Halil, Mustafa Cankurtaran, Burcu Balam Yavuz

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引用次数: 0

Abstract

Background and aim: Mild cognitive impairment (MCI) and dementia prevalence are expected to increase with aging. The DemTect is a very quick and easy tool to administer and recognize the early stages of dementia and MCI. In this study we aimed to evaluate the reliability and validity of a Turkish version of the DemTect and define cut off values for different age and educational levels. One of our aims is also to compare the sensitivity and specifity of the DemTect to other common screening tools.

Patients and methods: Fifty-four patients with MCI, 55 patients with dementia and 91 patients with subjective memory complaints (SMC) were enrolled in the study. The DemTect was translated into Turkish by forward-backward translation and compared with the Mini Mental State Examination (MMSE), the Quick Mild Cognitive Impairment Turkish version (QMCI-TR) and the Montreal Cognitive Assessment (MoCA). In order to test interrater reliability, the DemTect was administered to 11 patients, on the same day, by 2 trained raters. To establish test-retest reliability, the same rater scored the tool a second time on 11 patients within 2 weeks.

Results: The median age of the patients was 73 (min-max: 65-90) years, 54.5% were female. We found a strong correlation between DemTect scores and the MMSE, the QMCI, and the MoCA (r = 0.725, r = 0.816, r = 0.821, respectively; p < 0.001). In ROC analysis, the cut-off point of the DemTect to differentiate MCI from SMC was 11.5 with 92.6% sensitivity, 91.2% specificity, AUC 0.973 and the cut-off point of the DemTect to differentiate dementia from SMC was 9.5 with 96.4% sensitivity, 100% specificity, AUC 0.916. Cronbach α was 0.823. Intraclass correlation coefficient was 0.873 (95% CI: 0.598-0.964) for interrater reliability and 0.966 (95% 0.777-0.982) for test-retest reliability (Cronbach α = 0.932, 0.966 respectively).

Conclusion: The DemTect is a very reliable tool to assess Turkish patients with MCI and dementia.

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评估 MCI 和痴呆症的可靠工具：针对土耳其人口的 DemTect 验证研究。

背景和目的：随着年龄的增长，轻度认知障碍（MCI）和痴呆症的发病率预计会增加。DemTect 是一种非常快速简便的工具，可用于管理和识别痴呆症和 MCI 的早期阶段。在这项研究中，我们旨在评估土耳其版 DemTect 的可靠性和有效性，并确定不同年龄和教育水平的临界值。我们的目的之一还在于比较 DemTect 与其他常见筛查工具的敏感性和特异性：研究共招募了 54 名 MCI 患者、55 名痴呆症患者和 91 名主观记忆主诉（SMC）患者。通过正向-反向翻译将 DemTect 翻译成土耳其语，并与迷你精神状态检查 (MMSE)、快速轻度认知功能障碍土耳其语版 (QMCI-TR) 和蒙特利尔认知评估 (MoCA) 进行比较。为了测试评定者之间的可靠性，两名经过培训的评定者在同一天对 11 名患者进行了 DemTect 评定。为了确定测试重复可靠性，同一评分员在两周内对 11 名患者进行了第二次评分：患者的中位年龄为 73 岁（最小-最大：65-90 岁），54.5% 为女性。我们发现 DemTect 评分与 MMSE、QMCI 和 MoCA 之间存在很强的相关性（分别为 r = 0.725、r = 0.816、r = 0.821；p < 0.001）。在ROC分析中，DemTect区分MCI和SMC的临界点为11.5，灵敏度为92.6%，特异度为91.2%，AUC为0.973；区分痴呆和SMC的临界点为9.5，灵敏度为96.4%，特异度为100%，AUC为0.916。Cronbach α为0.823。评分者间可靠性的类内相关系数为 0.873（95% CI：0.598-0.964），重复测试可靠性的类内相关系数为 0.966（95% 0.777-0.982）（Cronbach α = 0.932，0.966）：DemTect是评估土耳其MCI和痴呆症患者的一种非常可靠的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Alzheimers Disease and Other Dementias GERIATRICS & GERONTOLOGY-CLINICAL NEUROLOGY

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： American Journal of Alzheimer''s Disease and other Dementias® (AJADD) is for professionals on the frontlines of Alzheimer''s care, dementia, and clinical depression--especially physicians, nurses, psychiatrists, administrators, and other healthcare specialists who manage patients with dementias and their families. This journal is a member of the Committee on Publication Ethics (COPE).