Derya Uluduz, Sevki Sahin, Taskin Duman, Serefnur Ozturk, Vildan Yayla, Nazire Afsar, Nevzat Uzuner, Ipek Midi, Nilgun Cinar, Mehmet Ali Sungur, Fusun Mayda Domac, Birsen Ince, Baki Goksan, Cemile Handan Misirli, Mustafa Bakar, Hasan Huseyin Kozak, Sena Colakoglu, Ali Yavuz Karahan, Eylem Ozaydin Goksu, Fatih Ozdag, Mehmet Guney Senol, Vedat Ali Yurekli, Ufuk Aluclu, Serkan Demir, Hayriye Kucukoglu, Serdar Oruc, Nilufer Yesilot, Ozge Yimaz Kusbeci, Bijen Nazliel, Firdevs Ezgi Ucan Tokuc, Hesna Bektas, Fatma Nida Tascilar, Emrah Aytac, Mustafa Gokce, Hale Zeynep Batur Caglayan, Ahmet Tufekci, Gulnur Uzuner, Dilek Necioglu Orken, Osman Ozgur Yalin, Uygar Utku, Arda Yilmaz, Hamit Genc, Murat Cabalar, Aysel Milanlioglu, Hakan Ekmekci, Burcu Zeydan, Sevim Baybas, Yuksel Kablan, Basak Karakurum Goksel, Mustafa Acikgoz, Hatice Kurucu, Seden Demirci, Taskin Gunes
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引用次数: 10
Abstract
Background: Early diagnosis of cerebral venous sinus thrombosis (CVST) associated with reproductive health-related risk factors (RHRF) including pregnancy, puerperium, and oral contraceptive (OC) use can prevent severe neurological sequelae; thus, the symptoms must be documented in detail for each group.
Methods: Out of 1144 patients with CVST, a total of 777 women were enrolled from a multicenter for the study of cerebral venous sinus thrombosis (VENOST). Demographic, biochemical, clinical, and radiological aspects were compared for 324 cases with RHRF and 453 cases without RHRF.
Results: The mean age of the RHRF (-) group (43.2 ± 13 years) was significantly higher than of the RHRF (+) group (34 ± 9 years). A previous history of deep venous thrombosis (3%), isolated cavernous sinus involvement (1%), cranial neuropathy (13%), comorbid malignancy (7%), and its disability scores after 12 months (9%) were significantly higher in the RHRF (-) group. The RHRF (+) group consisted of 44% cases of puerperium, 33% cases of OC users and 23% of pregnant women. The mean age was found to be higher in OC users (38 ± 9 years). A previous history of deep venous thrombosis was slightly higher in the pregnancy subgroup (4%). Epileptic seizures were more common in the puerperium group (44%).
Conclusion: The results of our study indicate that the risk of CSVT increases parallel to age, OC use, and puerperium period. In addition, when considering the frequency of findings and symptoms, epileptic seizures in the puerperium subgroup of the RHRF (+) group and malignancies in the RHRF (-) group may accompany the CSVT. In daily practice, predicting these risks for the CSVT and early recognition of the symptoms will provide significant benefits to patients.
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