Neurobrucellosis: a Case Report with an Unusual Presentation.

Q3 Medicine
Mostafa Meshref, Yara Amro, Mahmoud Ahmed Ebada
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引用次数: 0

Abstract

Background: Brucellosis is a highly infectious multi-systemic zoonosis, and it is caused by Gram-negative bacteria, Brucella. Despite the low incidence of neurobrucellosis, it is the most dangerous consequence of brucellosis.

Case report: A 30-year-old Sudanese male patient presented to our hospital with a complaint of fever associated with confusion for three days. He had signs of meningeal irritation in the form of neck stiffness, positive Kernig's, and Lesage's sign. The computerized tomography of the brain was normal. The CSF analysis showed a clear colorless sample with normal tension, decreased glucose, and slightly increased CSF protein level. We reviewed his occupational history; the patient was a farmer with regular contact with cattle and camels. The patient had positive Brucella antibodies for both B.Abortus and B. melitensis with a high titer (1/640). As described in various patents, we administrated triple therapy for brucellosis for two weeks. A marked improvement of the conscious level was observed, and the patient was back to normal within a few days post-treatment.

Conclusions: We encourage physicians to consider the diagnosis of neurobrucellosis with any neurologic sign without a known cause. Our case highlights the importance of occupational history in clinical medicine.

神经布鲁氏菌病:一个表现异常的病例报告。
背景:布鲁氏菌病是一种高度传染性的多系统人畜共患病,由革兰氏阴性菌布鲁氏菌引起。尽管神经布鲁氏菌病的发病率很低,但它却是布鲁氏菌病最危险的后果:病例报告:一名 30 岁的苏丹男性患者因发热伴意识模糊 3 天到我院就诊。他有脑膜刺激症状,表现为颈部僵硬、克尼格氏征和莱萨格氏征阳性。脑部计算机断层扫描结果正常。脑脊液分析显示样本无色透明,张力正常,葡萄糖含量降低,脑脊液蛋白水平略有升高。我们查看了他的职业史;患者是一名农民,经常与牛和骆驼接触。患者的布鲁氏菌抗体呈阳性,包括流产布鲁氏菌和梅毒布鲁氏菌,滴度很高(1/640)。根据多项专利的描述,我们对布鲁氏菌病进行了为期两周的三联疗法。治疗后几天,患者的意识明显好转,恢复正常:结论:我们鼓励医生在发现任何不明原因的神经症状时考虑神经布鲁氏菌病的诊断。我们的病例强调了职业史在临床医学中的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Recent patents on anti-infective drug discovery
Recent patents on anti-infective drug discovery Medicine-Pharmacology (medical)
CiteScore
2.40
自引率
0.00%
发文量
1
期刊介绍: Recent Patents on Anti-Infective Drug Discovery publishes review articles on recent patents in the field of anti-infective drug discovery e.g. novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery.
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