{"title":"The geometry of rest-spike bistability.","authors":"Giuseppe Ilario Cirillo, Rodolphe Sepulchre","doi":"10.1186/s13408-020-00090-z","DOIUrl":null,"url":null,"abstract":"<p><p>Morris-Lecar model is arguably the simplest dynamical model that retains both the slow-fast geometry of excitable phase portraits and the physiological interpretation of a conductance-based model. We augment this model with one slow inward current to capture the additional property of bistability between a resting state and a spiking limit cycle for a range of input current. The resulting dynamical system is a core structure for many dynamical phenomena such as slow spiking and bursting. We show how the proposed model combines physiological interpretation and mathematical tractability and we discuss the benefits of the proposed approach with respect to alternative models in the literature.</p>","PeriodicalId":54271,"journal":{"name":"Journal of Mathematical Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2020-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13408-020-00090-z","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Mathematical Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13408-020-00090-z","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Neuroscience","Score":null,"Total":0}
引用次数: 3
Abstract
Morris-Lecar model is arguably the simplest dynamical model that retains both the slow-fast geometry of excitable phase portraits and the physiological interpretation of a conductance-based model. We augment this model with one slow inward current to capture the additional property of bistability between a resting state and a spiking limit cycle for a range of input current. The resulting dynamical system is a core structure for many dynamical phenomena such as slow spiking and bursting. We show how the proposed model combines physiological interpretation and mathematical tractability and we discuss the benefits of the proposed approach with respect to alternative models in the literature.
期刊介绍：
The Journal of Mathematical Neuroscience (JMN) publishes research articles on the mathematical modeling and analysis of all areas of neuroscience, i.e., the study of the nervous system and its dysfunctions. The focus is on using mathematics as the primary tool for elucidating the fundamental mechanisms responsible for experimentally observed behaviours in neuroscience at all relevant scales, from the molecular world to that of cognition. The aim is to publish work that uses advanced mathematical techniques to illuminate these questions.
It publishes full length original papers, rapid communications and review articles. Papers that combine theoretical results supported by convincing numerical experiments are especially encouraged.
Papers that introduce and help develop those new pieces of mathematical theory which are likely to be relevant to future studies of the nervous system in general and the human brain in particular are also welcome.
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