Moonlighting Proteins.

IF 8.7 1区生物学 Q1 GENETICS & HEREDITY

Annual review of genetics Pub Date : 2020-11-23 Epub Date: 2020-09-01 DOI:10.1146/annurev-genet-030620-102906

Nadia Singh, Needhi Bhalla

引用次数: 53

Abstract

The single gene, single protein, single function hypothesis is increasingly becoming obsolete. Numerous studies have demonstrated that individual proteins can moonlight, meaning they can have multiple functions based on their cellular or developmental context. In this review, we discuss moonlighting proteins, highlighting the biological pathways where this phenomenon may be particularly relevant. In addition, we combine genetic, cell biological, and evolutionary perspectives so that we can better understand how, when, and why moonlighting proteins may take on multiple roles.

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兼职蛋白质。

单一基因、单一蛋白质、单一功能的假设越来越过时。许多研究表明，单个蛋白质可以月光，这意味着它们可以根据细胞或发育背景具有多种功能。在这篇综述中，我们讨论了兼职蛋白，强调了这种现象可能特别相关的生物学途径。此外，我们结合了遗传学，细胞生物学和进化的观点，以便我们能够更好地理解兼职蛋白质如何，何时以及为什么可能承担多种角色。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual review of genetics 生物-遗传学

CiteScore

18.30

自引率

0.90%

发文量

期刊介绍： The Annual Review of Genetics, published since 1967, comprehensively covers significant advancements in genetics. It encompasses various areas such as biochemical, behavioral, cell, and developmental genetics, evolutionary and population genetics, chromosome structure and transmission, gene function and expression, mutation and repair, genomics, immunogenetics, and other topics related to the genetics of viruses, bacteria, fungi, plants, animals, and humans.