Pathogenesis of Aging and Age-related Comorbidities in People with HIV: Highlights from the HIV ACTION Workshop.

Q1 Medicine

Pathogens and Immunity Pub Date : 2020-06-17 eCollection Date: 2020-01-01 DOI:10.20411/pai.v5i1.365

Dana Gabuzda, Beth D Jamieson, Ronald G Collman, Michael M Lederman, Tricia H Burdo, Steven G Deeks, Dirk P Dittmer, Howard S Fox, Nicholas T Funderburg, Savita G Pahwa, Ivona Pandrea, Cara C Wilson, Peter W Hunt

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引用次数: 32

Abstract

People with HIV (PWH) experience accentuated biological aging, as defined by markers of inflammation, immune dysfunction, and the epigenetic clock. They also have an elevated risk of multiple age-associated comorbidities. To discuss current knowledge, research gaps, and priorities in aging and age-related comorbidities in treated HIV infection, the NIH program staff organized a workshop held in Bethesda, Maryland in September 2019. This review article describes highlights of discussions led by the Pathogenesis/Basic Science Research working group that focused on three high priority topics: immunopathogenesis; the microbiome/virome; and aging and senescence. We summarize knowledge in these fields and describe key questions for research on the pathogenesis of aging and age-related comorbidities in PWH. Understanding the drivers and mechanisms underlying accentuated biological aging is a high priority that will help identify potential therapeutic targets to improve healthspan in older PWH.

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艾滋病毒感染者的衰老和与年龄相关的合并症的发病机制:HIV行动研讨会的亮点。

HIV感染者(PWH)经历了加重的生物衰老，这是由炎症、免疫功能障碍和表观遗传时钟标记所定义的。他们患多种与年龄相关的合并症的风险也较高。为了讨论艾滋病毒感染治疗中老龄化和年龄相关合并症的当前知识、研究差距和优先事项，美国国立卫生研究院项目工作人员于2019年9月在马里兰州贝塞斯达组织了一次研讨会。这篇综述文章描述了由发病机制/基础科学研究工作组领导的讨论的亮点，重点关注三个高优先主题:免疫发病机制;微生物/ virome;衰老和衰老。我们总结了这些领域的知识，并描述了PWH中衰老和年龄相关合并症的发病机制研究的关键问题。了解生物老化加剧的驱动因素和机制是当务之急，这将有助于确定潜在的治疗靶点，以改善老年PWH患者的健康寿命。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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