Responsible Translational Pathways for Germline Gene Editing?

IF 2.3 Q4 CELL & TISSUE ENGINEERING

Current Stem Cell Reports Pub Date : 2020-01-01 Epub Date: 2020-08-21 DOI:10.1007/s40778-020-00179-x

Bryan Cwik

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引用次数: 0

Abstract

Purpose of review: Continued development of gene editing techniques has raised the real possibility of clinical application of germline gene editing. These results, as well as reports of an unethical experiment which resulted in the birth of at least two children from edited embryos in 2018, have highlighted the urgency and importance of ethical issues about translational pathways for editing of human germline cells. Charting responsible translational pathways for germline gene editing requires tackling some significant and complex ethical issues.

Recent findings: A literature on development of clinical applications of germline gene editing is emerging, and several key ethical issues are coming into focus as major challenges for responsible translational pathways.

Summary: Potential clinical utility, clinical justification, and human subjects research for germline gene editing raise outstanding ethical questions. Work on these questions will help provide guidance to researchers and clinicians and direct translational projects toward justifiable applications.

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种系基因编辑的负责任转化途径？

综述的目的：基因编辑技术的不断发展提高了种系基因编辑临床应用的现实可能性。这些成果，以及 2018 年一项不道德实验导致至少两名儿童从编辑胚胎中出生的报道，凸显了人类种系细胞编辑转化途径伦理问题的紧迫性和重要性。为生殖系基因编辑规划负责任的转化途径需要解决一些重大而复杂的伦理问题：摘要：生殖系基因编辑的潜在临床实用性、临床合理性和人体研究提出了一些悬而未决的伦理问题。对这些问题的研究将有助于为研究人员和临床医生提供指导，并引导转化项目朝着合理的应用方向发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Stem Cell Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of stem cell research, therapy, ethics, commercialization, and policy. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.