Risk of cardiovascular disease with lipoprotein(a) in familial hypercholesterolemia: a review.

Archives of Medical Sciences. Atherosclerotic Diseases Pub Date : 2020-07-11 eCollection Date: 2020-01-01 DOI:10.5114/amsad.2020.97105

Jun Watanabe, Masato Hamasaki, Kazuhiko Kotani

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引用次数: 6

Abstract

Introduction: Lipoprotein(a) (Lp[a]) is a risk factor of cardiovascular disease (CVD). Familial hypercholesterolemia (FH), which exhibits high low-density lipoprotein cholesterol (LDL-C) levels, is a risk factor of CVD. The relationship of Lp(a) with CVD has been characterized in populations specific to FH.

Material and methods: Studies reporting on the relationship of Lp(a) with CVD among FH subjects via PubMed up to 2020 were reviewed.

Results: Eight studies were identified as eligible. In the meta-analyses, a high Lp(a) level was significantly and predictively associated with CVD compared to a low Lp(a) level in 2 cross-sectional studies (odds ratio = 2.57; 95% confidence interval (CI): 1.16-5.73) and 6 cohort studies (risk/hazard ratio = 1.91; 95% CI: 1.50-2.43). The totally integrated relative risk of these studies was 1.97 (95% CI: 1.57-2.46).

Conclusions: FH subjects with high Lp(a) levels can have a high CVD risk, and besides LDL-C, attention should be paid to Lp(a) levels in FH subjects.

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家族性高胆固醇血症患者与脂蛋白(a)相关的心血管疾病风险:综述

脂蛋白(a) (Lp[a])是心血管疾病(CVD)的危险因素。家族性高胆固醇血症(FH)表现为低密度脂蛋白胆固醇(LDL-C)水平高，是心血管疾病的危险因素。Lp(a)与CVD的关系已经在FH特异性人群中得到了表征。材料和方法:通过PubMed回顾了截至2020年FH受试者中Lp(a)与CVD关系的研究报告。结果:8项研究被确定为符合条件。在荟萃分析中，在2项横断面研究中，与低Lp(a)水平相比，高Lp(a)水平与CVD具有显著的预测相关性(优势比= 2.57;95%置信区间(CI): 1.16-5.73)和6项队列研究(风险/风险比= 1.91;95% ci: 1.50-2.43)。这些研究的完全综合相对风险为1.97 (95% CI: 1.57-2.46)。结论:高Lp(a)水平的FH患者有较高的CVD风险，除LDL-C外，FH患者还应注意Lp(a)水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Archives of Medical Sciences. Atherosclerotic Diseases

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