Endogenous Bufadienolide, Blood Pressure and Alcohol Withdrawal.

IF 1.5 Q3 PERIPHERAL VASCULAR DISEASE

Current Hypertension Reviews Pub Date : 2021-01-01 DOI:10.2174/1573402116999200819162306

Vladimir A Kashkin, Alexei Y Egorov, Evgeniy M Krupitsky, Alexei Y Bagrov

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Abstract

Background and objective: Previously, it was demonstrated that marinobufagenin (MBG) is implicated in the development of ethanol withdrawal in rats. It has been shown that ethanol withdrawal is associated with a pressor response in the alcoholics. We hypothesized that elevated levels of sodium pump ligand, MBG, would underline the increase in systolic blood pressure during alcohol withdrawal in humans.

Methods: The cohort included 9 patients with the diagnosis "alcohol dependence syndrome" (F10.(1-3) according to ICD-10). The blood samples for measurement of MBG concentration were collected from the subjects on the first day of withdrawal and after 7 days treatment of the abstinence. Arterial blood pressure was measured via plethysmography at the same time points.

Results: The beginning of the alcoholic abstinence was associated with the rise of arterial blood pressure with enhanced levels of plasma MBG. At day 7 following withdrawal, the systolic blood pressure and MBG levels were decreased to normal values.

Conclusion: The development of alcohol withdrawal is accompanied by an increase in arterial blood pressure, which is associated with increased plasma MBG concentration.

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内源性丁二烯内酯对血压和戒酒的影响。

背景与目的:先前有研究表明，marinobufagenin (MBG)与大鼠乙醇戒断的发生有关。研究表明，酒精戒断与酗酒者的升压反应有关。我们假设钠泵配体(MBG)水平的升高会强调人类在戒酒期间收缩压的升高。方法:纳入9例诊断为“酒精依赖综合征”的患者(根据ICD-10评分F10.(1-3))。分别于停药第一天和停药7天后采集受试者血样测定MBG浓度。在同一时间点通过容积描记仪测量动脉血压。结果:开始戒酒与动脉血压升高和血浆MBG水平升高有关。停药后第7天，收缩压和MBG水平降至正常值。结论:酒精戒断的发生伴随着动脉血压升高，而动脉血压升高与血浆MBG浓度升高有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Hypertension Reviews PERIPHERAL VASCULAR DISEASE-

CiteScore

4.80

自引率

0.00%

发文量

期刊介绍： Current Hypertension Reviews publishes frontier reviews/ mini-reviews, original research articles and guest edited thematic issues on all the latest advances on hypertension and its related areas e.g. nephrology, clinical care, and therapy. The journal’s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all clinicians and researchers in the field of hypertension.

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