Assessment of hepatitis and fibrosis using Gd-EOB-DTPA MRI in dogs.

IF 1.3 Q2 VETERINARY SCIENCES
Veterinary Record Open Pub Date : 2020-08-03 eCollection Date: 2020-01-01 DOI:10.1136/vetreco-2019-000371
Toshiyuki Tanaka, Hidetaka Nishida, Keiichiro Mie, Hiroki Yamazaki, Lee-Shuan Lin, Hideo Akiyoshi
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引用次数: 1

Abstract

Background: Gadoxetate sodium (Gd-EOB-DTPA) is taken into hepatocytes and excreted into the bile. Hepatocytes with reduced function or dysfunction due to hepatocellular carcinoma (HCC), hepatitis or hepatic fibrosis show impaired Gd-EOB-DTPA uptake. The purpose of the present retrospective case series was to assess the relationship between liver function and contrast enhancement using Gd-EOB-DTPA MRI.

Methods: Sixteen dogs with a histopathological diagnosis of liver disease, including six with HCC, three with nodular hyperplasia, two with hepatocellular adenoma, two with liver fibrosis and three with hepatitis were included in the study along with three dogs with suspected liver disease but no histopathological diagnosis of liver disease. Relative signal intensities (RSI) of the common bile duct and gall bladder were calculated, and their relationship with the following serum biochemical parameters was assessed: total bilirubin, alanine transaminase, alkaline phosphatase and albumin (Alb). To assess anatomical liver function, relative contrast enhancement indices (RCEI) of the liver were calculated, and differences were assessed between normal and diseased liver.

Results: RSI showed no significant differences between dogs without and with a histopathological diagnosis of liver disease (P=0.88) although they were significantly correlated with Alb (ρ=0.57, P=0.02) in dogs with a histopathological diagnosis of liver disease. RCEI was significantly higher in normal liver tissue than that in livers with hepatitis/fibrosis (P=0.048) and HCC (P=0.03) but not nodular hyperplasia/hepatocellular adenoma (P=0.51).

Conclusions: Gd-EOB-DTPA MRI may be potentially useful in the assessment of anatomical liver function in dogs with liver disease.

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Abstract Image

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Gd-EOB-DTPA MRI对犬肝炎和纤维化的评价。
背景:Gadoxetate钠(Gd-EOB-DTPA)被肝细胞吸收并排泄到胆汁中。由于肝细胞癌(HCC)、肝炎或肝纤维化导致功能降低或功能障碍的肝细胞显示Gd-EOB-DTPA摄取受损。本回顾性病例系列的目的是评估肝功能与Gd-EOB-DTPA MRI造影剂增强之间的关系。方法:16只经组织病理学诊断为肝脏疾病的狗,包括6只肝细胞癌、3只结节性增生、2只肝细胞腺瘤、2只肝纤维化和3只肝炎,以及3只疑似肝脏疾病但未经组织病理学诊断的狗。计算总胆管和胆囊的相对信号强度(RSI),并评估其与总胆红素、丙氨酸转氨酶、碱性磷酸酶和白蛋白(Alb)的关系。通过计算肝脏的相对对比增强指数(RCEI)来评估解剖性肝功能,并评估正常与病变肝脏的差异。结果:RSI与Alb有显著相关性(ρ=0.57, P=0.02),但在没有和有肝脏疾病组织病理学诊断的狗之间无显著差异(P=0.88)。正常肝组织的RCEI显著高于肝炎/纤维化(P=0.048)和HCC (P=0.03),而结节性增生/肝细胞腺瘤(P=0.51)无显著差异。结论:Gd-EOB-DTPA MRI可能对肝脏疾病犬的解剖性肝功能评估有潜在的应用价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Veterinary Record Open
Veterinary Record Open VETERINARY SCIENCES-
CiteScore
3.00
自引率
0.00%
发文量
25
审稿时长
19 weeks
期刊介绍: Veterinary Record Open is a journal dedicated to publishing specialist veterinary research across a range of topic areas including those of a more niche and specialist nature to that considered in the weekly Vet Record. Research from all disciplines of veterinary interest will be considered. It is an Open Access journal of the British Veterinary Association.
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