{"title":"Current Insights for the Management of Acne in the Modern Era.","authors":"Neha Singh, Apoorva Singh, Kalpana Pandey, Nimisha","doi":"10.2174/1574891X15999200729192138","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Acne vulgaris a chronic disease which is caused by blockage of the sebaceous gland is commonly seen in almost every human being at some point in their lives. There are 20-25% chances of progression of acne to severe cases, which leads to permanent scarring that results in psychological problems like depression, social isolation, lowered self-esteem, and lowered self-confidence.</p><p><strong>Objective: </strong>Though several conventional treatments are available in the market but still there are various adverse effects associated with topical anti-acne agents due to which it lacks patient compatibility. The present study is undertaken to find out the major shortcoming; why the current therapies do not give the desired therapeutic results.</p><p><strong>Conclusion: </strong>Novel drug delivery strategies can play a crucial role in the enhancement of topical delivery of anti-acne agents by escalating their dermal localization and reducing their adverse effects. Consumption of medicinal plants like Aloe vera, Withania somniferia etc. have clinical evidence regarding the effective management of acne. The current inclination towards nanotechnology is considerable due to several changes in the pharmaceutical research area. To secure the research work in different pharmaceutical fields, patents are filed against various agents like Galderma Research & Development have filed patents for adapalene and benzoyl peroxide for the management of acne vulgaris. The current review highlights the potential of various novel drug delivery approaches like liposomes, niosomes, ethosomes, transfersomes etc. in enhancing the topical delivery of anti-acne agents.</p>","PeriodicalId":20909,"journal":{"name":"Recent patents on anti-infective drug discovery","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Recent patents on anti-infective drug discovery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1574891X15999200729192138","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 3
Abstract
Background: Acne vulgaris a chronic disease which is caused by blockage of the sebaceous gland is commonly seen in almost every human being at some point in their lives. There are 20-25% chances of progression of acne to severe cases, which leads to permanent scarring that results in psychological problems like depression, social isolation, lowered self-esteem, and lowered self-confidence.
Objective: Though several conventional treatments are available in the market but still there are various adverse effects associated with topical anti-acne agents due to which it lacks patient compatibility. The present study is undertaken to find out the major shortcoming; why the current therapies do not give the desired therapeutic results.
Conclusion: Novel drug delivery strategies can play a crucial role in the enhancement of topical delivery of anti-acne agents by escalating their dermal localization and reducing their adverse effects. Consumption of medicinal plants like Aloe vera, Withania somniferia etc. have clinical evidence regarding the effective management of acne. The current inclination towards nanotechnology is considerable due to several changes in the pharmaceutical research area. To secure the research work in different pharmaceutical fields, patents are filed against various agents like Galderma Research & Development have filed patents for adapalene and benzoyl peroxide for the management of acne vulgaris. The current review highlights the potential of various novel drug delivery approaches like liposomes, niosomes, ethosomes, transfersomes etc. in enhancing the topical delivery of anti-acne agents.
背景:寻常痤疮是一种由皮脂腺阻塞引起的慢性疾病，几乎在每个人的一生中都会出现。痤疮发展到严重程度的几率为20-25%，这会导致永久性的疤痕，从而导致心理问题，如抑郁、社交孤立、自尊心下降和自信心下降。目的:虽然市场上有几种常规治疗方法，但由于缺乏患者兼容性，局部抗痤疮药物仍然存在各种不良反应。本研究旨在找出主要的不足之处;为什么目前的治疗方法不能达到预期的治疗效果。结论:新的给药策略可以通过提高抗痤疮药物的真皮定位和减少其不良反应，在增强抗痤疮药物局部给药方面发挥重要作用。食用药用植物，如芦荟，Withania somniferia等，在有效治疗痤疮方面有临床证据。由于药物研究领域的一些变化，目前对纳米技术的倾向相当大。为了保证在不同制药领域的研究工作，针对各种药物申请了专利，如Galderma research & Development已经申请了用于治疗寻常痤疮的阿达帕林和过氧化苯甲酰专利。本文综述了各种新型给药途径如脂质体、脂质体、脂质体、转移体等在增强抗痤疮药物局部给药方面的潜力。
期刊介绍：
Recent Patents on Anti-Infective Drug Discovery publishes review articles on recent patents in the field of anti-infective drug discovery e.g. novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery.
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