The Dynamic Interplay Between Mast Cells, Aging/Cellular Senescence, and Liver Disease.

Q2 Biochemistry, Genetics and Molecular Biology

Gene expression Pub Date : 2020-11-11 Epub Date: 2020-07-29 DOI:10.3727/105221620X15960509906371

Debjyoti Kundu, Lindsey Kennedy, Vik Meadows, Leonardo Baiocchi, Gianfranco Alpini, Heather Francis

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引用次数: 13

Abstract

Mast cells are key players in acute immune responses that are evidenced by degranulation leading to a heightened allergic response. Activation of mast cells can trigger a number of different pathways contributing to metabolic conditions and disease progression. Aging results in irreversible physiological changes affecting all organs, including the liver. The liver undergoes senescence, changes in protein expression, and cell signaling phenotypes during aging, which regulate disease progression. Cellular senescence contributes to the age-related changes. Unsurprisingly, mast cells also undergo age-related changes in number, localization, and activation throughout their lifetime, which adversely affects the etiology and progression of many physiological conditions including liver diseases. In this review, we discuss the role of mast cells during aging, including features of aging (e.g., senescence) in the context of biliary diseases such as primary biliary cholangitis and primary sclerosing cholangitis and nonalcoholic fatty liver disease.

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肥大细胞、衰老/细胞衰老和肝脏疾病之间的动态相互作用。

肥大细胞是急性免疫反应的关键参与者，脱颗粒导致过敏反应加剧。肥大细胞的激活可以触发许多不同的途径，促进代谢状况和疾病进展。衰老会导致不可逆的生理变化，影响包括肝脏在内的所有器官。在衰老过程中，肝脏经历衰老，蛋白质表达和细胞信号表型的变化，这些变化调节着疾病的进展。细胞衰老有助于年龄相关的变化。不出所料，肥大细胞在其一生中也会经历与年龄相关的数量、定位和激活变化，这对包括肝脏疾病在内的许多生理疾病的病因和进展产生不利影响。在这篇综述中，我们讨论了肥大细胞在衰老过程中的作用，包括在胆道疾病(如原发性胆道胆管炎、原发性硬化性胆管炎和非酒精性脂肪性肝病)中衰老的特征(如衰老)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gene expression 生物-生物工程与应用微生物

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Gene Expression, The Journal of Liver Research will publish articles in all aspects of hepatology. Hepatology, as a research discipline, has seen unprecedented growth especially in the cellular and molecular mechanisms of hepatic health and disease, which continues to have a major impact on understanding liver development, stem cells, carcinogenesis, tissue engineering, injury, repair, regeneration, immunology, metabolism, fibrosis, and transplantation. Continued research and improved understanding in these areas will have a meaningful impact on liver disease prevention, diagnosis, and treatment. The existing journal Gene Expression has expanded its focus to become Gene Expression, The Journal of Liver Research to meet this growing demand. In its revised and expanded scope, the journal will publish high-impact original articles, reviews, short but complete articles, and special articles (editorials, commentaries, opinions) on all aspects of hepatology, making it a unique and invaluable resource for readers interested in this field. The expanded team, led by an Editor-in-Chief who is uniquely qualified and a renowned expert, along with a dynamic and functional editorial board, is determined to make this a premier journal in the field of hepatology.