Actividad antifúngica de los enjuagues bucales frente a Candida albicans y Rhodotorula mucilaginosa: un estudio in vitro

IF 1.5 4区 生物学 Q4 MYCOLOGY
Rodrigo Alejandro Handschuh Briones , Evelyn Nicole Silva Arcos , Milton Urrutia , Patricio Godoy-Martínez
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引用次数: 0

Abstract

Background

Candida albicans and Rhodotorula mucilaginosa are yeasts of clinical importance in the oral cavity. In immunocompromised patients they can cause some pathologies that must be controlled with antimicrobials.

Aims

To evaluate and compare the antimicrobial efficacy of commercially available mouthrinses against strains of C. albicans and R. mucilaginosa.

Methods

The six mouthwashes studied in vitro were formulated (alone or in combination) with chlorhexidine (CHX) 0.12%, CHX 0.1%, CHX 0.05%, cetylpyridinium chloride (CPC) 0.075%, CPC 0.05%, and essential oils. Ten C. albicans and R. mucilaginosa isolates each were studied. The agar diffusion method (Mueller Hinton II), with incubation at 32 °C was used to evaluate the antifungal activity.

Results

The results of this study indicate that mouthwashes with CHX 0.1%, CHX 0.12%, CHX 0.05% + CPC 0.05%, CHX 0.12% + CPC 0.05% and CPC 0.075% have an antifungal effect against C. albicans and R. mucilaginosa. CHX 0.1% led to the broadest inhibition zone for C. albicans and R. mucilaginosa (25.65 ± 2.39 mm and 40.05 ± 3.31 mm). Essential oils did not show any antifungal activity. Statistical analysis showed no statistical difference between mouth rinses CHX 0.1%, CHX 0.12% and CHX 0.12% + CPC 0.05% (p = 0.0001) against C. albicans and R. mucilaginosa.

Conclusions

Mouthwashes with CHX showed higher antifungal activity against C. albicans and R. mucilaginosa than other mouthwashes studied.

漱口水对白色念珠菌和黏液红藻的抗真菌活性:一项体外研究
背景白色念珠菌和粘液红酵母是口腔中具有重要临床意义的酵母菌。在免疫功能低下的患者中,它们可引起一些必须用抗菌素控制的病理。目的评价和比较市售漱口水对白色念珠菌和黏液念珠菌的抑菌效果。方法分别以氯己定(CHX) 0.12%、CHX 0.1%、CHX 0.05%、氯化十六烷基吡啶(CPC) 0.075%、CPC 0.05%、香精油配制6种体外漱口水(单独或联合配制)。研究了10株白色念珠菌和黏液念珠菌。采用琼脂扩散法(Mueller Hinton II),在32°C孵育下评估其抗真菌活性。结果CHX 0.1%、CHX 0.12%、CHX 0.05% + CPC 0.05%、CHX 0.12% + CPC 0.05%和CPC 0.075%漱口水对白色念珠菌和黏液念珠菌均有抑菌作用。CHX 0.1%对白色念珠菌和黏液念珠菌的抑制区最宽(25.65±2.39 mm和40.05±3.31 mm)。精油没有显示出任何抗真菌活性。统计分析显示,CHX 0.1%、CHX 0.12%和CHX 0.12% + CPC 0.05%漱口水对白色念珠菌和黏液念珠菌的抑制作用无统计学差异(p = 0.0001)。结论CHX漱口水对白色念珠菌和黏液念珠菌的抑菌活性高于其他漱口水。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.90
自引率
0.00%
发文量
17
审稿时长
81 days
期刊介绍: Revista Iberoamericana de Micología (Ibero-American Journal of Mycology) is the official journal of the Asociación Española de Micología, Asociación Venezolana de Micología and Asociación Argentina de Micología (The Spanish, Venezuelan, and Argentinian Mycology Associations). The Journal gives priority to publishing articles on studies associated with fungi and their pathogenic action on humans and animals, as well as any scientific studies on any aspect of mycology. The Journal also publishes, in Spanish and in English, original articles, reviews, mycology forums, editorials, special articles, notes, and letters to the editor, that have previously gone through a scientific peer review process.
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