Very long chain fatty acids are an important marker of nutritional status in patients with anorexia nervosa: a case control study.

IF 2.3 4区 医学 Q2 PSYCHIATRY
BioPsychoSocial Medicine Pub Date : 2020-07-17 eCollection Date: 2020-01-01 DOI:10.1186/s13030-020-00186-8
Miki Shimizu, Keisuke Kawai, Makoto Yamashita, Masayasu Shoji, Shu Takakura, Tomokazu Hata, Megumi Nakashima, Keita Tatsushima, Kazunari Tanaka, Nobuyuki Sudo
{"title":"Very long chain fatty acids are an important marker of nutritional status in patients with anorexia nervosa: a case control study.","authors":"Miki Shimizu,&nbsp;Keisuke Kawai,&nbsp;Makoto Yamashita,&nbsp;Masayasu Shoji,&nbsp;Shu Takakura,&nbsp;Tomokazu Hata,&nbsp;Megumi Nakashima,&nbsp;Keita Tatsushima,&nbsp;Kazunari Tanaka,&nbsp;Nobuyuki Sudo","doi":"10.1186/s13030-020-00186-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Anorexia nervosa (AN) is a disease resulting in extreme weight loss. It is caused by multiple factors, including psychosocial, environmental, and genetic factors. A genetic abnormality affecting lipid metabolism has been recently reported in patients with AN. However, it is unknown whether lipid metabolism abnormalities in AN are caused by eating behavior, undernutrition, and/or genetic factors. The meaning of lipid metabolism in AN remains unclear. In particular, differences in the profiles of very long-chain fatty acids (VLCFAs) in patients with various types of AN have not been studied. This study aimed to determine changes to the fatty acid profile over a 3-month period, specifically that of long-chain fatty acids (LCFAs) and VLCFAs in patients with various types of AN.</p><p><strong>Methods: </strong>We evaluated 69 female patients with AN, subclassified as AN-restricting type (AN-R) and AN-Binge-Eating/Purging type (AN-BP). On admission and after 3 months of treatment, height, weight, body mass index, plasma and serum parameters, and plasma fatty acid concentrations were measured in all patients. The control group included 25 healthy, age-matched women. Comparisons between the groups were made using one-way ANOVA, while those between the various parameters at admission and after 3 months within each group were made using the Wilcoxon signed rank test.</p><p><strong>Results: </strong>On admission, the AN-R and the AN-BP groups had significantly higher levels of 18-24C and > 14C fatty acids (LCFAs and VLCFAs, respectively) than the control group. After 3 months of treatment, both groups showed high levels of 14-24C fatty acids. The levels of VLCFAs (C22:0 and C24:0) and LCFA (C18:3) after 3 months of treatment remained high in both AN groups relative to the control group.</p><p><strong>Conclusions: </strong>Eating behaviors appear to be associated with levels of LCFAs. Lipid metabolism abnormalities under conditions of starvation in AN might have a genetic basis and appear to be associated with VLCFA (C22:0 and C24:0) and LCFA (C18:3) levels.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"14 ","pages":"14"},"PeriodicalIF":2.3000,"publicationDate":"2020-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13030-020-00186-8","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BioPsychoSocial Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13030-020-00186-8","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 4

Abstract

Background: Anorexia nervosa (AN) is a disease resulting in extreme weight loss. It is caused by multiple factors, including psychosocial, environmental, and genetic factors. A genetic abnormality affecting lipid metabolism has been recently reported in patients with AN. However, it is unknown whether lipid metabolism abnormalities in AN are caused by eating behavior, undernutrition, and/or genetic factors. The meaning of lipid metabolism in AN remains unclear. In particular, differences in the profiles of very long-chain fatty acids (VLCFAs) in patients with various types of AN have not been studied. This study aimed to determine changes to the fatty acid profile over a 3-month period, specifically that of long-chain fatty acids (LCFAs) and VLCFAs in patients with various types of AN.

Methods: We evaluated 69 female patients with AN, subclassified as AN-restricting type (AN-R) and AN-Binge-Eating/Purging type (AN-BP). On admission and after 3 months of treatment, height, weight, body mass index, plasma and serum parameters, and plasma fatty acid concentrations were measured in all patients. The control group included 25 healthy, age-matched women. Comparisons between the groups were made using one-way ANOVA, while those between the various parameters at admission and after 3 months within each group were made using the Wilcoxon signed rank test.

Results: On admission, the AN-R and the AN-BP groups had significantly higher levels of 18-24C and > 14C fatty acids (LCFAs and VLCFAs, respectively) than the control group. After 3 months of treatment, both groups showed high levels of 14-24C fatty acids. The levels of VLCFAs (C22:0 and C24:0) and LCFA (C18:3) after 3 months of treatment remained high in both AN groups relative to the control group.

Conclusions: Eating behaviors appear to be associated with levels of LCFAs. Lipid metabolism abnormalities under conditions of starvation in AN might have a genetic basis and appear to be associated with VLCFA (C22:0 and C24:0) and LCFA (C18:3) levels.

Abstract Image

Abstract Image

超长链脂肪酸是神经性厌食症患者营养状况的重要标志:一项病例对照研究。
背景:神经性厌食症(Anorexia nervosa, AN)是一种导致体重急剧下降的疾病。它是由多种因素引起的,包括社会心理、环境和遗传因素。最近在AN患者中报道了一种影响脂质代谢的遗传异常。然而,尚不清楚AN的脂质代谢异常是否由饮食行为、营养不良和/或遗传因素引起。脂质代谢在AN中的意义尚不清楚。特别是,尚未研究不同类型AN患者的甚长链脂肪酸(VLCFAs)谱的差异。本研究旨在确定3个月期间脂肪酸谱的变化,特别是长链脂肪酸(LCFAs)和VLCFAs在不同类型AN患者中的变化。方法:对69例女性AN患者进行评估,分为AN限制型(AN- r)和AN暴食/泻型(AN- bp)。入院时和治疗3个月后,测量所有患者的身高、体重、体质指数、血浆和血清参数以及血浆脂肪酸浓度。对照组包括25名年龄相仿的健康女性。组间比较采用单因素方差分析,入院时和3个月后各组各参数间比较采用Wilcoxon符号秩检验。结果:入院时,AN-R组和AN-BP组患者18-24C和> 14C脂肪酸(分别为LCFAs和VLCFAs)水平明显高于对照组。治疗3个月后,两组患者的14-24C脂肪酸水平均较高。治疗3个月后,两组患者的vlcfa (C22:0和C24:0)和LCFA (C18:3)水平均高于对照组。结论:饮食行为似乎与LCFAs水平有关。AN饥饿条件下脂质代谢异常可能具有遗传基础,似乎与VLCFA (C22:0和C24:0)和LCFA (C18:3)水平有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
3.60
自引率
0.00%
发文量
23
审稿时长
18 weeks
期刊介绍: BioPsychoSocial Medicine is an open access, peer-reviewed online journal that encompasses all aspects of the interrelationships between the biological, psychological, social, and behavioral factors of health and illness. BioPsychoSocial Medicine is the official journal of the Japanese Society of Psychosomatic Medicine, and publishes research on psychosomatic disorders and diseases that are characterized by objective organic changes and/or functional changes that could be induced, progressed, aggravated, or exacerbated by psychological, social, and/or behavioral factors and their associated psychosomatic treatments.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信