Association between Visceral Fat and Bone Mineral Density in Both Male and Female Patients with Adult Growth Hormone Deficiency.

IF 3.4 Q2 BIOCHEMICAL RESEARCH METHODS

Biochemistry Research International Pub Date : 2020-07-05 eCollection Date: 2020-01-01 DOI:10.1155/2020/5079625

Linman Li, Li Zhong, Xiaoya Zheng, Wenyi You, Yunting Wang, Jihui Yu, Xun Wu, Wei Ren, Gangyi Yang

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引用次数: 1

Abstract

Aim: Adult growth hormone deficiency (AGHD) is associated with an increased risk of fractures. The interactions between various body composition and bone are known to be complex in nature. However, very few studies have examined this crosstalk in AGHD. In this study, we sought to investigate the relationship between various parameters of body composition and bone mineral density (BMD) as well as determine the role of visceral fat in determining the bone mass in patients with AGHD.

Methods: We conducted a cross-sectional study on 57 patients with AGHD. Anthropometry, biochemistry, and analysis of body composition and BMD were performed according to standard protocols. Male and female patients were classified into those with osteoporosis and those without osteoporosis (normal subjects and patients with osteopenia). Further, we analyzed the correlation between the BMD and measurements obtained for various body composition parameters in male and female AGHD patients.

Results: Our findings indicated that among female AGHD patients, those with osteoporosis had a significantly higher levels of fat mass (FM) and visceral adipose tissue mass (VATM) (both, P < 0.05) than those without osteoporosis. Further, Pearson correlation analysis showed that the values of age, body mass index (BMI), FM, and VATM correlated negatively with BMD in women with AGHD (all P < 0.05); however, this association was not noted in men. After adjusting for the other covariates, VATM was found to be independently correlated with the BMD in female patients with AGHD.

Conclusions: A close correlation was noted between VATM and BMD in female patients with AGHD.

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男性和女性成人生长激素缺乏症患者内脏脂肪和骨密度的关系

目的:成人生长激素缺乏症(AGHD)与骨折风险增加有关。各种身体成分和骨骼之间的相互作用在本质上是复杂的。然而，很少有研究检查AGHD中的这种串扰。在本研究中，我们试图探讨身体组成各参数与骨密度(BMD)之间的关系，并确定内脏脂肪在AGHD患者骨量决定中的作用。方法:对57例AGHD患者进行横断面研究。根据标准方案进行人体测量、生物化学、身体成分和骨密度分析。将男性和女性患者分为骨质疏松和非骨质疏松(正常受试者和骨质减少患者)。此外，我们分析了男性和女性AGHD患者的骨密度与各种身体成分参数测量值之间的相关性。结果:我们的研究结果显示，在女性AGHD患者中，骨质疏松患者的脂肪质量(FM)和内脏脂肪组织质量(VATM)水平均显著高于无骨质疏松患者(P < 0.05)。Pearson相关分析显示，AGHD女性年龄、体重指数(BMI)、FM、VATM值与BMD呈负相关(P < 0.05);然而，在男性中没有发现这种关联。在校正其他协变量后，发现VATM与女性AGHD患者的BMD独立相关。结论:女性AGHD患者VATM与骨密度密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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