Is there a relationship between epicardial fat tissue thickness and Tp-Te/QT ratio in healthy individuals?

Archives of Medical Sciences. Atherosclerotic Diseases Pub Date : 2020-06-05 eCollection Date: 2020-01-01 DOI:10.5114/aoms.2020.96147
Mücahid Yılmaz, Hidayet Kayançiçek, Nevzat Gözel, Ertuğrul Kurtoğlu, Özlem Seçen, Pınar Öner, Yusuf Çekici, Mehmet Nail Bilen, Suat Demirkıran, Ökkeş Uku
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Abstract

Introduction: Epicardial fat is a tissue that releases many proinflammatory and atherogenic mediators, with endocrine and paracrine effects on the heart. In this study, the implication of the EFT thickness (EFTt) on transmural dispersion of repolarisation (TDR) was analysed utilizing the T-wave peak to end interval (Tp-Te), the Tp-Te dispersion (Tp-Te (d)), and the Tp-Te/QT ratio.

Material and methods: One thousand seven hundred and thirteen subjects were enrolled in the research. The subjects were chosen to be healthy individuals, without any cardiovascular/systemic disorders or risk factors for atherosclerosis. Transthoracic echocardiography (TTE) was applied to all subjects, and EFTt was measured in both diastole and systole. The ECG measurements were taken from standard 12-lead surface ECG.

Results: Correlation analysis revealed that the EFTt is highly associated with the Tp-Te interval, Tp-Te/QT ratio, Tp-Te (d), increasing age, body mass index (BMI), body surface area (BSA), left ventricular (LV) mass, LV mass index, plasma glucose during fasting, triglycerides, and low-density lipoprotein cholesterol.

Conclusions: The study results showed that increased EFTt was associated with increased TDR values of Tp-Te, Tp-Te (d), and Tp-Te/QT ratio, even in the absence of other factors that could increase TDR and EFTt. Therefore, it can be stated that increased EFTt may cause an increase the risk for ventricular arrhythmia.

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健康人心外膜脂肪组织厚度与Tp-Te/QT比值有关系吗?
心外膜脂肪是一种释放许多促炎和动脉粥样硬化介质的组织,对心脏有内分泌和旁分泌作用。在这项研究中,利用t波峰端间隔(Tp-Te)、Tp-Te色散(Tp-Te (d))和Tp-Te/QT比值分析了EFT厚度(EFTt)对复极化跨壁色散(TDR)的影响。材料与方法:本研究共纳入1713名受试者。受试者均为健康个体,无任何心血管/全身疾病或动脉粥样硬化危险因素。所有受试者均采用经胸超声心动图(TTE),在舒张期和收缩期均测量EFTt。心电图测量采用标准12导联体表心电图。结果:EFTt与Tp-Te间期、Tp-Te/QT比值、Tp-Te (d)、年龄增长、体重指数(BMI)、体表面积(BSA)、左室(LV)质量、左室质量指数、空腹血糖、甘油三酯、低密度脂蛋白胆固醇高度相关。结论:研究结果显示,即使在没有其他可能增加TDR和EFTt的因素的情况下,EFTt升高与TDR值Tp-Te、Tp-Te (d)和Tp-Te/QT比值升高相关。因此,可以认为EFTt升高可能导致室性心律失常的风险增加。
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